پديد آورنده :
ايل بگي بهرام آبادي، مرجان
عنوان :
ساخت، مشخصه يابي و ارزيابي خواص مكانيكي و زيستي داربست نانوكامپوزيتي هيدروكسي آپاتيت - برديجيت
مقطع تحصيلي :
كارشناسي ارشد
گرايش تحصيلي :
شناسايي و انتخاب مواد
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده مهندسي مواد
صفحه شمار :
دوازده،82ص.: مصور
استاد راهنما :
رحمت اله عمادي، كيوان رئيسي
استاد مشاور :
مهشيد خرازيها
استاد داور :
محمدرضا سائري، شيدا لباف
تاريخ ورود اطلاعات :
1394/12/04
چكيده فارسي :
4 4 2 بررسي مورفولوژي داربستهاي كامپوزيتي 35 4 5 آناليز عنصري با تفكيك انرژي پرتوايكس 15 4 1 تعيين ميزان تخلخل و چگالي 95 4 7 تعيين خواص مكانيكي 11 4 1 ارزيابي ميزان زيستفعالي و زيستتخريبپذيري داربستهاي هيدروكسيآپاتيت برديجيت 21 4 9 ارزيابي زيستسازگاري 17 فصل پنجم جمع بندي 5 1 نتيجهگيري 47 5 2 پيشنهادها 57 17 مراجع چكيده انگليسي 31 8 نه
چكيده انگليسي :
84 Synthesis characterization and evaluation of mechanical and biological properties of hydroxyapatite bredigite nanocomposite scaffold Marjan Eilbagi m eilbeigi@ma iut ir Department of Materials Engineering Isfahan University of Technology 84156 83111 Isfahan IranDegree M Sc Language FarsiSupervisors Rahmatollah Emadi E mail remadi@cc iut ac irKeyvan Raeissi E mail k raeissi@cc iut ac irAbstractIn recent years a major challenge in biomaterials is to produce porous materials with similarcomposition to bone tissue Hydroxyapatite HA is characterized by its high biocompatibility andclose chemical similarity to biological apatite and has been used as an artificial bone graft materialin many clinical trials Porous HA is more degradable and osteoconductive than bulkHydroxyapatite However the mechanical properties of porous HA are too weak for load bearingapplications Results confirmed that the mechanical Physical and biological properties of HAporous scaffolds could be modified using the addition of suitable secondary components CaO SiO2 MgO bioceramics demonstrated high bioactivity and good mechanical properties Bredigite isa Ca Si and Mg containing bioceramic Results showed that Ca Si Mg containing bioceramics notonly possessed an improved mechanical strength when compared with hydroxyapatite andceramics but also were degradable The aim of this study is to develop three dimensional HA bredigite porous scaffolds using space holder technique HA and bredigite nanopowders weresynthesized via sol gel and combustion sol gel respectively and then various ratios of HA andbredigite nanoparticles 5 10 and 15 wt bredigite were mechanically combined Then afteraddition of poly vinyl alcohol PVA and sodium chloride as space holder they compacted usingcompression In order to sinter the compacted powders remove sodium chloride and P A powdersand develop porous structure samples were heat treated at 13 0 c for 2h X ray diffraction XRD technique was utilized to confirm presence of the desired phases in the structure and also todetermine the crystallite size and crystallinity of the prepared scaffolds The crystallite sizes werecalculated by Scherrer and modified Scherrer equation and the results were compared To evaluatethe shape and size of the particles and crystallites A transmission electron microscopy TEM wasapplied and the size of HA nanopowder particles was calculated around 30 nm Scanning electronmicroscopy SEM was applied in order to study morphology and surface of nanopowders andscaffolds before and after soaking in simulated body fluid SBF Energy dispersive X rayspectroscopy EDS was utilized to evaluate the chemical composition and distribution of elementsin scaffolds Furthermore axial compression test was applied to study the mechanical properties ofscaffolds Bioactivity of different scaffolds was investigated by soaking them in SBF for variousperiods 14 and 28 days The concentration of calcium and phosphorus ions in SBF and thecontent of pH of SBF were determined for various periods by ICP OES method and pH meter respectively In order to verify the biocompatibility of scaffolds MTT assay was applied Resultsshowed that composite scaffolds with pore sizes in the range of 220 310 m appearance porosityof 63 75 and compressive strength of 1 1 7 MPa were developed SEM images of scaffoldsafter soaking in SBF depicted the tiny agglomerated bone like apatite particles Also biocompatibility evaluations by MTT method showed that scaffolds could stimulate cellproliferation of Osteoblast like cells and they did not have any cytotoxicity as compared to controlsample Considering the results obtained it seems that manufactured scaffolds could be a goodcandidate for bone tissue engineering Keywords Porous materials Hydroxyapatite Bredigite Mechanical properties Biocompatibility 84
استاد راهنما :
رحمت اله عمادي، كيوان رئيسي
استاد مشاور :
مهشيد خرازيها
استاد داور :
محمدرضا سائري، شيدا لباف
