پديد آورنده :
صادقي، حميد
عنوان :
سنتز و شناسايي كمپلكس هاي جدي (Ni(II),Co(II),Zn(II),Cu(II),Cd(II با ليگاند دارويي ايندومتاسين و بررسي خواص ضد باكتري ، سميت سلولي ، ضداكسيدانتي و برهمكنش با DNA و BSA
مقطع تحصيلي :
كارشناسي ارشد
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي
صفحه شمار :
نه،61ص.: مصور
استاد راهنما :
حسين چيني فروشان
توصيفگر ها :
ضد سرطاني , ضد اكسيدانتي , كمپلكس كبالت , كمپلكس كادميم , كمپلكس روي , كمپلكس مس , كمپلكس نيكل
استاد داور :
فاطمه داور، كاظم كرمي
تاريخ ورود اطلاعات :
1395/04/05
چكيده انگليسي :
Synthesis and characterization of new complexes of Cd II Cu II Zn II Ni II Co II with indomethacin drug as ligand and their investigation Antibacterial Cytotoxicity antioxidant DNA and BSA interaction studies Hamid Sadeghi Hamidsadeghi90@yahoo com Date of submission Department of Chemistry Isfahan University of Tecnology Isfahan 84156 83111 IranDegree M S Language farsi H Chiniforooshan assist prof chini@cc iut ac irAbstractThe cadmium II nickel II zinc II cobalt II and copper II complexes with a non steroidal anti inflammatory drug indomethacin Hindo in the presence of thiocyanate ligand SCN have beensynthesized and characterized The complexes K2 Cd indo 2 SCN 2 K Ni indo 2 SCN K Zn indo 2 SCN K Co indo 2 SCN and K2 Cu indo 2 SCN 2 where indo is ionic form ofindomethacin have been structurally characterized by means of vibrational spectroscopy The cadmiumcomplex is in dimeric form that has been structurally characterize by X Ray cristalography ComplexK2 Cd indo 2 SCN 2 has been investigated for its antibacterial and anticancer activities and hasappeared more effective than Cisplatin drug against two different types of cancer cells MCF 7 and T 24 at the same in vitro conditions K2 Cd indo 2 SCN 2 complex is more effective than free indomethacinligand in antioxidant activity This complex has stronger interaction with DNA and BSA than freeindomethacin ligand Kyewords cytotoxicity antibacterial anticancer BSA interaction DNA interaction cobalt complex cadmium complex zinc complex copper complex nickel complex
استاد راهنما :
حسين چيني فروشان
استاد داور :
فاطمه داور، كاظم كرمي
