پديد آورنده :
خرسندي، زهرا
عنوان :
اصلاح سطح نانو لوله هاي كربني چندديواره به چند روش مختلف به منظور تهيه نانو كاتاليست هاي جديد پالاديم و كبالت و كاربرد آن ها در واكنش هاي جفت شدن و بررسي خواص ضد استروژني برخي محصولات از طريق محاسبات داكينگ مولكولي
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان دانشكده شيمي
صفحه شمار :
شانزده،[121]ص.: مصور،جدول،نمودار
يادداشت :
ص.ع.به فارسي و انگليسي
استاد راهنما :
عبدالرضا حاجي پور
استاد مشاور :
حسين فرخ پور
توصيفگر ها :
حلال سبز پلي اتيلن گليكول
استاد داور :
مجيد مقدم، عبدالحسين دباغ، حسين توكل
تاريخ ورود اطلاعات :
1395/08/15
كد ايرانداك :
ID928 دكتري
چكيده فارسي :
فصل چهارم داده هاي تكميلي ۴ طيف شناسي برخي محصولات ۴ ساختارهاي بهينه شده مشتقات و تصاوير سه بعدي برهمكنش آنها با گيرنده استروژن مراجع ۵ چكيده انگليسي ده يازده
چكيده انگليسي :
Modification of multiwall carbon nanotubes by some various methods for preparation of nanocatalsyt contianing palladium and cobalt and their applications in cross coupling reactions and investigation anti estrogen activityof some products using molecular docking studies Zahra Khorsandi Khorsandiz 91@yahoo com Department of Chemistry Iran Isfahan 84156 83111 Isfahan University of TechnologySupervisor name Prof Abdol Reza Hajipour E mail address haji@cc iut ac irAdvisor name Dr Hosaein Frrokhpour Isfahan University of Technology College of Chemistry Pharmaceutical Research LaboratoryIslamic Republic of Iran Isfahan 84156Abstract In this thesis the important heterocylic compounds included benzimidazol benoxazoles andoxothiazoles have been synthesized through carbon heteroatom coupling reaction using heterogonouscobalt nanoparticles The potential applications of these compounds as estrogen receptor ligand have beeninvestigated by molecular docking studies and one of them was found as best one The heterogonous catalyst field have been developed using multiwalled carbon nanotube as supports andpalladium and low cost cobalt The application of these catalyst in Heck cross coupling reaction wasinvestigated Mulltiwalled carbon nanotubes was modified by various methods to tagged several ligands Atfirst imidazolum ionic liquid have been supported on multiwalled carbon nanotube via ionic approach andits cobalt catalyst was prepared In continues NHC carben ligand have been attached directly on carbonnanotubes and its complex with cobalt was made One of the ways of modification of carbon nanotubes issupported of amino through carboxylic group herein we used methylhistinate as ligand to make palladiumcomplex Keywords C C coupling C Heteroatom coupling multiwalled carbon nanotubes cobalt palladium docking studyCancer is one of the main causes of death second only to heart disease The most frequently diagnosedcancer in women is breast cancer especially in industrialized countries According to previous studies moreover the physicochemical properties of the synthetic ER ligands molecular shape as expected to beextremely important for the access and interaction with the receptors The described molecules herein aresimilar in size shape and polarity to known compounds which have demonstrated inhibitory activity in thelife cycle of both ER negative and ER positive breast cancer cells The benzimidazoles benzoxazoles andbenzothiazoles frameworks are a very valuable class of heterocyclic compounds in the area of drug design based on reported results some their derivatives can make good cytotoxic effects on the MCF 7 cell lineand have been used widely in the structure of some potent estrogen ligands Therefore considerable effortsto found new efficient and facile methodologies to improve their synthesis would be logical In the past fewdecades numerous synthetic strategies fortheir synthesis have been reported However the developmentgreen and simple methods for synthesis of these compounds remain complicated A facile and high yielding method for the synthesis of 2 aryl benzoxazoles benzimidazole andbenzothiazoles is reported employing cobalt oxide nanoparticles The cobalt oxide nanoparticles were usedas a convenient green easy available and highly efficient heterogeneous nano catalyst which promotedcyclization cross coupling reactions without ligands and or additives This procedure has advantages suchas simplicity of work up eco friendly of reaction medium low cost and mild conditions of reaction Inaddition to the binding modes of synthesized compounds to estrogen receptor were studied by molecular
استاد راهنما :
عبدالرضا حاجي پور
استاد مشاور :
حسين فرخ پور
استاد داور :
مجيد مقدم، عبدالحسين دباغ، حسين توكل
