12260

11231

كارشناسي ارشد

شيمي معدني

اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي

1395

يازده، 43ص.: مصور، جدول، عكس(رنگي)، نمودار

ص. ع. به فارسي و انگليسي

1395/12/09

كتابنامه

شيمي

شيمي

ID11231

44 Copper II cobalt II and nickel II complexes of juglone synthesis structure DNA interaction and enhanced cytotoxicity Mahrokh Fooladivanda Department of chemistry Isfahan University of Technology Isfahan 84156 83111 Iran Degree M Sc Language Farsi Supervisor Dr Hossein Chiniforoshan chini@cc iut ac irAbstractThree novel copper II cobalt II and nickel II complexes of juglone Jug containing1 10 phenanthroline phen ligand M Jug 2 phen M Cu II 1 Co II 2 and Ni II 3 have been synthesized and characterized using elemental analysis and spectroscopicstudies Their interactions with calf thymus DNA were investigated using viscositymeasurements UV visible and fluorescence spectrophotometric methods The catalyticactivities on DNA cleavage of the complexes 1 3 were studied which copper complex 1showed better catalyst activity in the DNA cleavage process than complexes 2 and 3 The in vitro cytotoxic potential of the complexes 1 3 against human cervical carcinoma HeLa human liver hepatocellular carcinoma HepG 2 and human colorectaladenocarcinoma HT 29 cells indicated their promising antitumor activity with quite lowIC50 values in the range of 0 09 1 89 M which are 75 times lower than those ofcisplatin Keywords Metal complex DNA binding Cytotoxicity Juglone

حسين چيني فروشان

كاظم كرمي، محمد ديناري