12543

1037 دكتري

دكتري

شيمي آلي

اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي

1396

پانزده، 134ص.: مصور، جدول، نمودار

ص. ع. به فارسي و انگليسي

عبدالرضا حاجي پور

عليرضا نجفي چرمهيني

داور داخلي: عبدالحسين دباغ، حسين توكل; داور خارجي: شهرام تنگستاني نژاد

1396/04/24

كتابنامه

شيمي

شيمي

ID1037 دكتري

Application of Palladium Nano Catalyst Immobilized on Chitosan in Heck and Suzuki Coupling Reactions Carbonylation of Aryl Halides and Preparation of Benzimidazole Derivatives Zeinab Tavangar Rizi E mail z tavangar@ch iut ac ir Department of Chemistry Isfahan University of Technology 84156 83111 Isfahan IranSupervisor name Abdol Reza Hajipour E mail address haji@cc iut ac irAdvisor name Alireza Najafi ChermahiniDepartment Graduate Program Coordinator Alireza Najafi ChermahiniPharmaceutical Research Laboratory College of Chemistry Isfahan University of Technology Isfahan84156 Islamic Republic of IranAbstractIn this thesis we reported a novel catalyst system for immobolized palladium metal containing magnetic nanoparticles core ImmPd 0 MNPs for Heck and Suzuki coupling carbonylation of aryl halides and synthesis of benzimidazole derivatives The catalyst wascharacterized by TEM SEM XRD EDX FT IR TGA and VSM The ImmPd 0 MNPs is found as an exceptionally mild and versatile catalyst for Heck andSuzuki reactions of aryl iodides and bromides at room temperature The catalyst was simplyreused by an external magnet from the reaction mixture and recycled several times Theresults showed that the catalyst was very active and stable Moreover these reactions wascarried out in water as a green and environmentally acceptable solvent This phosphine free catalyst also demonstrated good activity for carbonylation reactions containing alkoxycarbonylation aminocarbonylation carbonylative Suzuki and carbonylativehiyama reactions Various substituted aryl iodides tolerated the reaction conditions and awide variety of amides esters and ketones were synthesized in the presence of Mo CO 6 as acarbon monoxide reagent The effects of solvent base and temperature were studied in allreactions The developed catalytic system avoids the use of phosphine ligands and can bereused for up to eight consecutive cycles Finally this catalytic system was used for the synthesis of benzimidazoles starting from o phenylenediamines and amines It is possible to use a tertiary a secondary and even aprimary amine as the substrate for a palladium mediated process to get 2 substitutedbenzimidazoles Primary amines are the most suitable reagents for the atom economy of theoverall process that resulted to be general as several different substituted benzimidazoleswere obtained in good yield

عبدالرضا حاجي پور

عليرضا نجفي چرمهيني

داور داخلي: عبدالحسين دباغ، حسين توكل; داور خارجي: شهرام تنگستاني نژاد