شماره راهنما :
1196 دكتري
پديد آورنده :
صالحي، شيرين
عنوان :
كنترل نرخ در شبكه‌هاي مخابرات مولكولي با تأكيد بر سيستم‌هاي تحويل داروي هدفمند
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده برق و كامپيوتر
صفحه شمار :
چهارده، [۱۴۷]ص.: مصور، جدول، نمودار
استاد راهنما :
نغمه سادات مؤيديان
استاد مشاور :
شقايق حق‌جوي جوانمرد، [ادوارد آلاركون]، [جوزپ سوله پرتا]
توصيفگر ها :
مخابرات مولكولي مبتني بر پراكنش , كنترل نرخ ارسال نانو ماشين , تحويل داروي هدفمند , افزايش طول عمر , پاسخ ضربه كانال , مدل كردن پذيرنده
استاد داور :
محمدحسين منشئي، فروغ السادات طباطبا
تاريخ ورود اطلاعات :
1397/03/07
رشته تحصيلي :
برق و كامپيوتر
دانشكده :
مهندسي برق و كامپيوتر
كد ايرانداك :
ID1196 دكتري
چكيده انگليسي :
Rate Control in Molecular Communication Networks with Emphasis on Targeted Drug Delivery Systems Shirin Salehi shirin salehi@ec iut ac ir March 10 2018 Department of Electrical and Computer Engineering Isfahan University of Technology Isfahan 84156 83111 IranSupervisor Dr Naghmeh Sadat Moayedian moayedian@cc iut ac irAdvisor Prof Shaghayegh Haghjooy Javanmard Advisor Prof Eduard Alarcon Advisor Prof Josep Sol Pareta Department Graduate Program Coordinator Prof Mohammad Reza Taban Department of Electrical and Computer Engineering Isfahan University of Technology Isfahan 84156 83111 Iran Department of Physiology Isfahan University of Medical Sciences Isfahan 81746 73461 Iran NaNoNetworking Center in Catalunya N3Cat Universitat Polit cnica de Catalunya 08034 Barcelona SpainAbstractMolecular communication is a new communication paradigm among nanomachines biological and artificial which is inspiredby biological systems Nanomachines have limitations in terms of energy and reservoir Drug molecules may also be expensiveand releasing a large amount of them has an adverse effect on the healthy parts of the body In this dissertation a multipletransmitter local drug delivery system is suggested with fixed rate In this scenario only transmitters inside the target arearelease medications Therefore the non target areas of the body are not intoxicated The minimum density of required nan otransmitters to synthesize an ideal concentration is obtained Then a single and multiple transmitter local drug delivery systemis designed with optimal releasing rates The optimal release rate of each nanotransmitter is derived in order to minimize thetotal rate of drug release while maintaining the least effective concentration in every part of the tumor Subsequently threeprotocols are introduced to improve the lifetime of this drug delivery system The first two protocols are the direct extension ofthe proposed drug delivery system while the third protocol makes farther inactive nanomachines release encapsulated drugs This protocol with a smarter design is capable of extending lifetime with less adverse effects and more ease of use Encapsu lated drugs are incapable of reaction unless they are unpacked in a drug transmitter nanomachine and converted to free drugs It is shown that we can assume equal rates for all backup nanomachines This protocol increases the time interval betweenconsecutive administrations which improves the mental health of patients and reduces the costs of treatment Afterward thediffusion based molecular communication channel impulse response is studied in presence of a probabilistic absorber in 1 D to3 D environments This probabilistic absorber can be considered as a receptor model To this end the system is analyzed withrandom walk and Markov chain and the concentration due to an instantaneous or continuous emission is obtained in presenceof the probabilistic absorber Then modeling the receptor with M M 1 1 queue the absorption probability arrival rate andabsorption rate can be obtained versus the transmitter emission rate Key WordsDiffusion based Molecular Communication Nanomachine Releasing Rate Control Targeted Drug Delivery Lifetime Improve ment Channel Impulse Response Receptor Modeling IntroductionMolecular communication MC is the transmission and reception of chemical signals or molecules and is an interdisciplinaryresearch area that spans nanotechnology biology and communication technology MC can be used to interconnect multiplenanomachines Such interconnection of nanomachines is called nanonetwork Akyildiz et al 2008 MC is a promisingapproach in the field of drug delivery due to biocompatibility It may improve the efficacy of a targeted drug delivery system
استاد راهنما :
نغمه سادات مؤيديان
استاد مشاور :
شقايق حق‌جوي جوانمرد، [ادوارد آلاركون]، [جوزپ سوله پرتا]
استاد داور :
محمدحسين منشئي، فروغ السادات طباطبا
