13878

12615

كارشناسي ارشد

پليمر

اصفهان: دانشگاه صنعتي اصفهان، دانشكده مهندسي شيمي

۱۳۹۷

چهارده،۹۰ص.: مصور، جدول، نمودار

طيبه بهزاد، لاله قاسمي مباركه

مهشيد خرازيها

سعيد نوري خراساني، افسانه ولي پوري

1397/07/02

كتابنامه

مهندسي شيمي

مهندسي شيمي

ID12615

91 Abstract The skin is a heterogeneous viscoelastic substance whose properties depend on the age theperson and the location of the skin Various diseases or environmental injuries such as accidents surgeries chemical and chronic burns can easily destroy skin tissue Application of nanofiber matsmade by electrospining method due to high surface area morphological control and otherproperties in medicine and tissue engineering science is the most important tool for researchers inrestoring damaged tissues Poly caprolactone PCL is a non toxic synthetic polyesters withsuitable physical properties and semi crystalline Gelatin Gel is a natural hydrophilic polymersynthesized from amino acids linked by peptide bonds Cellulose nanofibers CNF are one of themost important natural crystalline polymers with low density high mechanical properties andfavorable economic value In this research scaffolds of these three biodegradable andbiocompatible polymers with a concentration of 10 w w PCL Gel polymer in AA FA 3 1 solvents with different ratios 70 30 P70 50 50 P50 and 30 70 P30 and different percentagesof cellulose nanofibers of 1 2 3 and 6 were prepared and electrically spun under optimizedconditions To optimize the solution conditions viscosity and electrical conductivity of differentpolymer concentrations were measured Fourier transform spectroscopy was carried out to confirmthe presence of all three polymer materials To investigate the quality of elctrospun mats morphology and porosity of nanofibers mats were examined via SEM In addition the mechanicalproperties and crystallinity of the electrospun scaffolds were studied using Zwick machine andXRD respectively Moreover the hydrophilic properties of the scaffolds were investigated throughthe contact angle measurement The rate of degradation of polymeric scaffolds immersed in PBSsolution at 37 C to 60 days and also the morphological studies of scaffolds and ultimatelyFibroblast cell culture and endemic sclera Osmith MTT on scaffolds were studied Among the most important results reaching a 95 98 nanometer diameter for nanofibers inthe P70 compound the mean pore size of all nanowire polymeric scaffolds ranging from1 6 to 6 5 nm increasing the hydrophilic properties after addition CNF increasingmechanical properties and maintaining the stability of nanoparticulate polymer scaffoldingwith P70 polymer ratio after adding CNF to 2 by weight and achieving a tensile stress of3 24 MPa and a tensile modulus of 25 75 MPa the highest crystallinity of 56 82 afterAdding CNF and enhancing the adhesion and growth of fibroblast cells following theaddition of CNF to polymeric PCL Gel scaffolds Keywords Tissue engineering Poly caprolactone Gelatin Gel Cellulose nanofiber CNF Fibroblast cell

طيبه بهزاد، لاله قاسمي مباركه

مهشيد خرازيها

سعيد نوري خراساني، افسانه ولي پوري