توصيفگر ها :
سرطان , تومور , متابوليسم گليكوليز , اثر واربورگ , نظريه بازي تكاملي , بازي كالاي عمومي , ATP
چكيده انگليسي :
Warburg effect analysis of cancer cells with two methods replicator equation and public good game Zahra Abbaspour Asadolah z abbaspour@ph iut ac ir Jan 19 2019 Department of Physics Isfahan University of Technology Isfahan 84156 83111 Iran University Code IUT 77142 Degree M S c Language Farsi supervisor Dr F Shahbazi shahbazi@cc iut ac ir Abstract Recently statistics shows that the cancer is the most deadly disease in the world In fact genetic information changes can lead to uncontrolled abnormal growth of cells and this is the general definition of cancer cells There are many open questions in this area which captured my interest to reaserch in this topic One of these challenges is the Warburg effect This phenomenon is related to the metabolism of a cancer cell and states that cancer cells even in the presence of oxygen instead of providing energy from a more efficient respiration process energize through the inefficient glycolysis process and this energy forms the adenosine triphosphate molecule Or the same ATP is released In this study we examined the cancer cells population which performs by two metabolisms of respiration and glycolysis and it is based on evolutionary game theory By appllying replicator equation and public good game we have examined tu mor population to observe whether the results of the public good game are closer to the reality of the tumor heterogeneity Also by changing the public good game parameters we could show that treatment with metabolic methods Therefore that cells instead of energizing with Warburg effect can more efficiently respiration their energy through a more efficient process than treatment Radiation therapy and chemotherapy Keywords cancer tumor glycolysis metabolism Warburg effect evolutionary game theory public good game ATP
