Simultaneously with the occurrence of climatic phenomena, common diseases between humans and animals have also spread in different parts of the world. Land use change and urban, industrial and agricultural development, in addition to affecting climate, also affect human health and wildlife. Human encroachment on nature and pristine areas may cause disease, and threaten the health of society. In fact, climate change and land use are two factors affecting the ecosystem and life cycle of insects. In this study, the effects of climatic elements and environmental factors on skin leishmaniasis in Kashan were studied. This study is of analytical-descriptive type. Climatic data using SPSS software and Pearson correlation were compared with 3949 cases of cutaneous leishmaniasis from 86 to 98. Also, the preva‎lence of cutaneous leishmaniasis cases in the city with land use maps, land cover, rain map, thermal zoning and map Elevations were measured. Pearson correlation analysis showed a negative correlation between skin leishmaniasis cases and spring temperature and a positive correlation with total rainfall and winter. Spatial distribution of cases of cutaneous leishmaniasis was observed in Kashan city. The preva‎lence of this disease was higher near Kashan desert belt from Abuzidabad to Ab-e Shirin, landfill, around agricultural lands, main roads and suburbs. The frequency of leishmaniasis is significantly negatively related to the reduction of spring temperature to the desired level for the activity of sandflies. Rainfall has also caused a significant increase in this disease. Autumn had the highest and spring had the least cases of leishmaniasis. In the spatial distribution of the disease, the connection with the desert areas where the disease reservoir mice lived and the agricultural lands where the reproduction and activity of sandflies were evident. Since the optimum temperature for the activity of sandflies is 18 to 21 in the season and the average temperature of Kashan in this season is higher than this value, so the inverse relationship of skin leishmaniasis with temperature can be justified as well as the positive relationship between skin leishmaniasis and Precipitation can also be attributed to the effect of precipitation on decreasing temperature. The accumulation of major disease centers near desert areas is due to the habitat of host rats in these areas and agricultural areas have provided favorable conditions for their feeding. The old road of Kashan is a place of accumulation of industries and accumulation of industrial and construction debris, which are a suitable place for hiding mosquitoes. The results of this study can be used to identify critical points of the disease and control and prevention of the target and this model can be used to identify areas prone to disease in other areas.

حسين مرادي

عليرضا سفيانيان

سعيد پورمنافي- محسن احمدي