Abstract Despite the significant properties of titanium and its alloys as implants for in vivo applications, the lack of proper osseointegration with tissue is one of the major problems of this metal. So, the development of bioactive coatings on the surface of these alloys can be useful in achieving the desired interaction with bone tissue. The purpose of the present study was to prepare the nanocomposite coatings of bredigite-graphene oxide (GO) on Ti6Al4V substrate by dip-coating method. In this regard, after synthesis of bredigite nanopowder using a combustion sol-gel was eva‎luated by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Then, the nanocomposite coating of bredigite- graphene oxide containing various concentrations of bredigite (4, 8 and 12 wt %) was prepared using a simple dip-coating method on Ti6Al4V. The coatings were examined using X-ray diffraction pattern, scanning electron microscopy, Fourier transform infrared spectroscopy (FTIR), surface roughness measurement, water contact angle measurement, adhesion strength, potentiodynamic polarization test, electrochemical impedance spectroscopy (EIS), in vitro bioactivity eva‎luation in the simulated body fluid (SBF) and Biocompatibility eva‎luation. The results showed that increasing the bredigite concentration upon 8 wt%, resulted in the formation of a uniform and dense coating. The corrosion assays also confirmed the improved corrosion resistance of the bredigite-GO coatings compared to uncoated substrate. The roughness and hydrophilicity of the optimum coating also increased. The results of cytotoxicity analysis showed that all coatings over time caused cell proliferation and no toxicity on Ti6Al4V surface. The adhesion test also showed that as the amount of bredigite increased, the adhesion also increased.

رضا اميني

مهشيد خرازيها