The confied impinging jet method has been used as a simpler and more functional method to reduce the particle size of loratadine to increase its solubility. The ratio of anti-solvent to solution ratio, drug concentration, Reynolds number and stabilizing concentration increased in this study process. The chemical and physical properties of loratadine nanoparticles were investigated by various analyzers. The size of loratadine nanoparticles was optimized by changing the ratio of solvent to solvent flow rate, drug concentration, Reynolds number and using Tween 80 as stabilizer. The best size of loratadine nanoparticles was obtained with a narrow size distribution of about 53 nm. It was found that loratadine nanoparticles completely dissolved after 11 minutes and that the dissolution rate of loratadine nanoparticles was 50 times faster than raw loratadine. Also, the nucleation and growth kinetics of loratadine were obtained by using different types of microchannels. Drawing induction time curves and nucleation rates with the model of the classical theory of nucleation, expressed homogeneous and heterogeneous nucleation in high and low supersaturations. The amount of interfacial free energy obtained from the induction time test and the nucleation rate were equal to (18.99-20.37 mj / m2). The kinetic power of crystal growth in high supersaturations was 2.47 and in high supersaturations were 2.26. The growth kinetics of loratadine well follows the multinucleated superficial growth mechanism. Experimental data on crystal growth were examined with growth dispersion models and size-dependent growth models that were in good agreement with the M-4 model. Also, the crystallization process was simulated with impinging jets with the Euler-Euler approach and with the Eulerin method using ANSYS-Fluent software. By combining the PBE with CFD, the size distribution of the crystals was obtained with and without aggregation. The effect of collision angle, Reynolds, concentration and length of the outlet nozzle in the microchannel was investigated and the results were eva‎luated with the available experimental data.

مسعود حق شناس فرد، رضا ضرغامي

محسن نصراصفهاني، روح الله صادقي

عليرضا سليماني نظر، احمدرضا پيشه ور، ارجمند مهرباني، مهدي ستاري