Abstract In this study polycaprolactone/gelatin/calcium doped barium titanate polymer scaffolds were fabricated by electrospinning method and the function of the scaffold for bone applications and treatment of periodontal diseases was investigated. The behavior of samples containing 3%, 5% and 7% of barium titanate nanoparticles was studied. Electronspun nanofibers using scanning electron microscope (SEM), X-ray diffraction patterns (XRD), Infrared spectroscopy (FT-IR) pattern, EDS analysis, mechanical analysis, Inductively coupled plasma (ICP), cell culture analysis and MTT toxicity assays, bioactivity and biodegradability assays were eva‎luated. According to the SEM images the 7% barium titanate nanoparticle sample fibers obtained using a distance of 25cm from the collector, 12.5KV voltage and 15 ml/h feed rate obtained better results comparect to the other two samples and were determined as the optimal scaffold. XRD and FT-IR analysis confirmed the interaction of the polymer on the barium titanate nanoparticles and the presence of BaTiO3 ceramics in the samples. EDS eva‎luated the amount of elements in the material used to create the scaffolds. Bioactive and biodegradable analyses confirmed the compatibility of the sample for biological applications. ICP analysis and SEM images of samples immersed in SBF solution showed reduced amounts of Ca and P elements and proved the formation of hydroxyapatite on the scaffold. Cell analysis confirmed osteoblast cell proliferation and non-toxicity of the sample. The 7% ceramic sample was introduced as the optimal sample

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