3D bioprinting as a novel substitute for classical cell culture has attracted the attention of many researchers in recent years. Damage to tissues is one of the common difficulties that causes pain for many people around the world every year. Although, it is hoped that, by evolution of the bioprinting technology these pains will be eliminated. Effectiveness of the final bio-printed product is highly dependent on the acuuracy of the printing process. The more the printed tissue resembles the original one the higher ability of cells to retrieve the native tissue. Due to the variety in body tissues, scientists are developing new bioinks with different applications and specifications. This is why eva‎luation of the final product has received less cosideration. One of the most significant factors that affects quality of the printed tissue is the flow rate out of the nozzle. Therefore, in this study with the focus on the extrusion-based bioprinting, a mathematical model of the syringe pump has been derived. Thereupon, a disturbance observer based input-output linearization controller for the flow rate of the syringe pump has been designed. This controller has successfully simulated and the results have met the requirements. In order to make implementation possible, a 3D bioprinter with syringe pump as its fluid dispensing unit has been constructed. The build plate has equipped with a loadcell to measure the flow rate. Finally with a proper chioce of hardware, implementation of the controller has been carried out and the results were provided.

محمد دانش , مهدي كاروان

احسان فروزمهر

مهدي كشميري , مهدي كاروان