Magnetic nanoparticles have developed various biomedical and therapeutic applications. Many natural polymers such as polysaccharides are biocompatible and their aerogel application in drug delivery systems has been successfully investigated. Therefore, polysaccharide materials are suitable for nanoparticle coating and drug loading for biomedical applications such as cancer treatment. In this research, in the first step, cobalt ferrite nanoparticles were synthesized by sol-gel method. Olive leaf extract was used as a complexing agent and sucrose as a gelling agent to prevent aggregation of the product. The obtained gel was converted into a dry gel by an oven and then calcined at temperatures of 500, 600, and 700 °C for 3 hours. By checking the FTIR analysis of the synthesized samples, the temperature of 700 °C was chosen as the optimal calcination temperature. The characterization of samples synthesized with different volumes of olive leaf extract was investigated by XRD, TEM, FESEM, EDS, and Map. The average size of the synthesized nanoparticles was estimated to be about 24 nm using the TEM image. The magnetic properties of the synthesized nanoparticles were also investigated using the Vibrating Sample Magnetometer (VSM) test, and the highest saturation magnetization property was obtained 58.55 emu/g for the E1 sample. In the second step of this research, the polysaccharide precursor of gum tragacanth was used to make an aerogel. The effect of operating pressure of 12, 15 and 18 MPa on the specific surface area, the total volume of the holes and the average diameter of the holes of the final product was eva‎luated. The results of the BET test showed that the operating conditions of 15 MPa lead to the production of magnetic aerogel with a maximum specific surface area of 131.47 m2/g. In addition, nitrogen adsorption-desorption isotherm for all samples according to the division of the IUPAC system is of type IV isotherms. To investigate the morphology of the magnetic aerogel, FESEM images were prepared, which show its porous structure well. In addition, EDS and Map test were prepared from pure gum tragacanth aerogel and magnetic aerogel carrying drug, and the EDS results show a significant increase of cobalt and ferrite elements in magnetic aerogel compared to pure gum tragacanth aerogel. Moreover, by examining the map images of cobalt and ferrite elements, it was found that the magnetic nanoparticles are properly dispersed in the aerogel structure. In addition, the increase of Cl in the magnetic aerogel indicates the presence of doxorubicin drug in the product. 5 and 10 mass percent of magnetic nanoparticles were used to produce magnetic aerogel and VSM analysis was taken from both of the samples. By considering the results of the analysis, it was found that the magnetic properties of the aerogel increase as the percentage of magnetic nanoparticles increases.

محمد قريشي , فاطمه داور

بهزاد آقابراري

مهران غياثي , علي اكبر دادخواه , محمد كاظميني