The drug delivery system based on nanoparticles has attracted the attention of researchers due to its ability to enable targeted drug release, increase effectiveness, and reduce side effects. Additionally, the use of nanotechnology in drug delivery allows for drugs to be sent to previously inaccessible areas. Cancer is one of the deadly disease. Among common cancers, breast cancer is the second leading cause of cancer-related deaths among women. Traditional drug delivery systems have disadvantages such as high toxicity, poor drug stability, and low efficiency. Therefore, nanoparticle-based drug delivery systems can be used for targeted drug delivery to specific organs or locations. In this thesis, a graphitic carbon nitride bed was synthesized, and [Cu(Cur)2] and [Zn(Cur)2] complexes were loaded onto its surface. Then, the nanoparticles of [Cu(Cur)2], [Zn(Cur)2] complexes, and the nanocomplexes loaded onto graphitic carbon nitride bed were prepared using an ultrasonic bath. The successful synthesis of nanoparticles was confirmed using FT-IR, UV-Vis, FE-SEM, ICP and XRD analyses. These nanoparticles have a high surface area and can be used in drug delivery systems. The anticancer effect of the prepared compounds and their targeted drug delivery in MCF-7 cell line were eva‎luated using the MTT test. It should be noted that both curcumin ligand and graphitic carbon nitride bed possess synergistic cytotoxic effects due to their anticancer properties. The IC50 of [Cu(Cur)2] nanocomplex was reported as 29.7 % for MCF-7 cell line. Hence, [Cu(Cur)2] nanocomplex can be used as a sutaible choice for preparing anticancer drugs.

حسن حداد زاده

پرستو كشتي‌آرا

فاطمه داور , علي حسين كيانفر