In this research, ZIF-67, which is synthesized from cobalt (Ⅱ) nitrate and 2-methylimidazole organic binders, was used, because the large surface area and high porosity in these compounds increase the drug loading capacity and provide significant therapeutic results. brings along In this regard, ZIF-67 was first prepared and used to determine its structural characteristics, porosity description, thermal stability measurement, and morphology determination using different analytical methods such as: X-ray diffraction pattern (XRD), scanning electron microscope images (SEM) and heat test. gravimetry (TGA) and zeta potential analysis were used. Then, palladium complexes were placed on these nanoparticles as a proposed drug, and identification of functional groups and loaded molecules inside the ZIF cavities using methods such as Fourier transform infrared (FT-IR), X-ray energy diffraction spectroscopy (EDX) and spectra The magnetic resonance of 1H NMR and 13C NMR and the release of this complex in the extracorporeal environment were performed by ultraviolet-visible spectroscopy. became. We will also encapsulate palladium complexes used in cancer treatment as drugs inside ZIF-67. In this regard, to increase the efficiency of the designed system, surface modification was done with CuS nanoparticles coated with PVP, and the connectors in the designed drug delivery system were protonated in the microenvironment of cancer cells, which have a lower pH than healthy body cells, and the coordination link between Cobalt (II) and the 2-methylimidazole linker are broken in it, and as a result, ZIF-67 is decomposed and the drug is released. it happens In this research, the release of palladium complex in free and loaded form on PVP-CuS@ZIF-67 nanocarrier was eva‎luated in vitro using dialysis bag method in phosphate buffer with pH=5.7 and pH=7.4. The results show that the release of the palladium complex in the first 10 hours at acidic pH and in the free state was 60% and 82%, respectively, and it has a higher release than at neutral pH and in the loaded state (50% and 72%, respectively) because The purpose of loading on the substrate is to control the release of the complex in a certain period of time and in a concentration- and time-dependent manner. In this research, the successful loading of the complex on the nanocarrier is observed.

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محمد ديناري , فاطمه داور