This study aims to compare proton therapy an‎d carbon ion therapy for liver cancer treatment while investigating the effects of range compensation. A 3 cm diameter tumor within the liver was modeled using a MIRD phantom. Proton an‎d carbon ion irradiation of this phantom were simulated using Geant4 code, with subsequent calculation of dose delivery to both tumor tissue an‎d healthy tissue. The optimal therapeutic ratio for both radiation modalities was compared. Initial dose calculations an‎d therapeutic ratio assessments were performed for monoenergetic proton an‎d carbon ion beams with cross-sections matching the tumorʹs dimensions. Subsequently, the beam was configured as a set of concentric annular beams with energies adjusted according to the thickness of tumor regions facing irradiation. This approach incorporated range compensation by modulating incident beam energy across different radial positions. Results shows that the therapeutic ratio for proton beams with range compensation (using concentric annular beams) increased by 30% compared to monoenergetic beams, while carbon ion beams showed a 42% improvement. Furthermore, proton beams with range compensation achieved approximately 26% higher therapeutic ratio than similarly configured carbon ion beams. Secondary particles were also calculated. Finaly, the results for different conditions were compared an‎d analyzed for both proton an‎d carbon ion beams.

ظفراله كلانتري

مريم حسنوند

سروش شاكري , سجاد مري