Abstract Due to the increasing need for biocompatible an‎d biodegradable scaffolds for use in bone tissue engineering, in this study, two types of scaffolds, PC (containing PLA an‎d CCTO) an‎d PCT (containing PLA, CCTO an‎d β-TCP), were prepared using 3D printing technology an‎d were eva‎luated in terms of structural, biological an‎d drug delivery properties. The results showed that adding CCTO to PLA increased the compressive strength, so that after adding 5% by weight of CCTO, the compressive strength increased from 55 MPa to 89 MPa. Also, adding 10% by weight of β-TCP along with 5% by weight of CCTO also showed a compressive strength of 86 MPa, which indicates an increase in compressive strength. The results of the bioactivity test showed that the PCT scaffold performed better than the PC scaffold, an‎d the PC degradation rate was 4.85 an‎d the PC degradation rate was 4.85. The cytotoxicity results showed that the cell viability in PC was 97% compared to the control sample, while PCT was 92%. In the drug release section, PC scaffold released 96% of the drug in 5 hours, while PCT released this amount in 24 hours. Finally, the CCTO enhancer can be considered as a promising material that has entered bone tissue engineering as an enhancer.

عرفان عقيلي , تقي اصفهاني

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