ارزيابي خواص مكانيكي، زيستي و رهايش دارو داربست كامپوزيتي پلي لاكتيك اسيد - Sr2MgSi2O7رهايش شده با سريم توليد شده به روش چاپگر سه بعدي

This study investigates the mechanical an‎d biological properties of scaffolds composed of polylactic acid (PLA) an‎d Sr2MgSi2O7 doped with cerium (1 an‎d 2 wt% cerium oxide). The research aims to enhance therapeutic capabilities in tissue repair by utilizing novel an‎d effective materials. The scaffolds—both with an‎d without cerium doping—demonstrate significant potential for providing favorable bioactive properties; the results indicate their suitability as viable options for clinical applications in this field. Non-toxicity tests confirm the materialsʹ biocompatibility, demonstrating that the cerium dopant is non-toxic at the concentrations employed. One of the key advantages regarding bone repair is the growth of hydroxyapatite on the samples, which was clearly demonstrated through the bioactivity test. Furthermore, the incorporation of Sr2MgSi2O7 into the polylactic acid scaffold matrix enhanced compressive properties, thereby ensuring the strength an‎d stability of the scaffolds for clinical applications. Additionally, drug delivery assessments indicate favorable performance, with materials containing cerium exhibiting higher drug loading capacities an‎d release rates. The results indicate superior structural quality an‎d the presence of active luminescent centers, with broadban‎d excitation driven by the transition from the 8S₇/₂ (4f⁷) ground state to the 4f65d1[8S7/2(4f7)4f65d1] excited state; this property could facilitate the monitoring of scaffold degradation levels within the body without requiring additional procedures.

تقي اصفهاني , عرفان عقيلي

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