4188

3959

كارشناسي ارشد

شيمي نساجي و علوم الياف

اصفهان : دانشگاه صنعتي اصفهان، دانشكده نساجي

1387

سيزده، 154، [II] ص. : مصور، جدول، نمودار

ص. ع. به : فارسي و انگليسي

محمد مرشد، ژاله ورشوساز

22/7/1387

ابوالفضل اصلاني، سعيد نوري خراساني

مهندسي نساجي

ID3959

به فارسي و انگليسي : قابل رويت در نسخه ديجيتال

AbstractIn this research nanofibers containing CipHCl drug are electrospun from biodegradable polymer in3 steps for the purpose of healing of deep burns The first step was the preparation of solutions ofPVAc PVC with mass ratios of 0 100 25 75 50 50 75 25 100 0 in aqueous acetic acid solvents of40 50 60 and subsequently were electrospun In order to produce optimum nanofibers theconcentration of each component was determined In the second step 0 3 V V of sulfuric acid was added to all the solvents for improving thequality of electrospinning and nanofibers The results showed that the electrical conductivity wasincreased by increasing sulfuric acid and the solutions viscosity slightly were decreased while theaverage nanofiber diameters was decreased significantly i e in blend with mass ratio of 25 75 theaverage nanofiber diameter was decreased from 503 7 to 80 nm In the third step electrospinning was carried out by adding the crystal powder of drug to thepolymer solutions which led to the improvement of nanofiber structure end quality By makingsuch a fine nanofibers the degree of swelling was increased in such a way that for PVA nanowebs in 24 hr the degree of swelling was 2092 for nanofibers with diameter of 180 nm thisenhancement was an increase of 150 For analysis of the physical structure and probable chemical interference of drug and polymer DSC analysis and for assessing the effect of electrospinning on physical structure of polymer anddrug and the distributing of drug in polymer chains XRD was used FTIR was applied to assurethat there has been no interference between drug polymers polymer polymer andpolymer solvents UV spectrophotometer was used to evaluate the amount of drug release fromnanofiber non woven fibers in which the phosphate buffer with PH 6 8 was applied The drug release results illustrated that the type of polymer polymer ratios the amount of drug nanofiber diameter and thickness of nanofiber layer influence significantly on release profile burstrelease and rate and total time of drug release in such a way that PVA nanofiber web containing5 drug had the maximum drug release time and the minimum burst release The burst releasewas controlled by increasing the nanofiber diameter and nanofiber web thickness separately Totally this study illustrated that by changing the parameters such as type of polymer polymerratios amount of drug web thickness and nanofiber diameter different formulations will beobtained leading to various profiles for CipHCl drug release Healing of the deeper burn theformulation with higher ratio of PVA due to the higher swelling is preferred

محمد مرشد، ژاله ورشوساز

ابوالفضل اصلاني، سعيد نوري خراساني