پديد آورنده :
عرب زاده، عباس
عنوان :
مطالعه و اندازه گيري داروهاي كاپتوپريل، بنزرازيد و لودوپابروش امپدانس اسپكتروسكوپي و ولتامتري با استفاده از اصلاحگرهاي كلرپرومازين و كلرآنيل
مقطع تحصيلي :
كارشناسي ارشد
گرايش تحصيلي :
شيمي تجزيه
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي
صفحه شمار :
شانزده، 94، [II] ص: نمودار، جدول
يادداشت :
ص.ع به: فارسي و انگليسي
استاد راهنما :
علي اصغر انصافي، تقي خياميان
توصيفگر ها :
طيف بيني امپدانس الكتروشيميايي , كرونوآمپرومتري
تاريخ نمايه سازي :
10/3/1388
استاد داور :
محمد سراجي، محمد تقي جعفري
چكيده فارسي :
به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي
چكيده انگليسي :
Study Determination of Captopril Benserazide and Levodopa using Impedance spectroscopic Voltammetric techniques using Chlorpromazine Chloranil as mediator Abbas Arabzadeh A Arabzadeh@ch iut ac ir 08 03 2009 Department of Chemistry Isfahan University of Technology Isfahan 84156 83111 IranDegree M Sc Language FarsiAli Asghar Ensafi ensafi@cc iut ac irTaghi Khayamiyan taghi@cc iut ac irAbstract In the first part of this project a sensitive voltammetric method has been developed for thedetermination of captopril The oxidation of captopril has been studied at a glassy carbon electrode byelectrocatalytic effect of chlorpromazine as a homogenous mediator using electrochemical impedancespectroscopy cyclic and linear sweep voltammetry chronoamperometry and as diagnostic and measurementtechniques Cyclic voltammetric investigation showed that although captopril didn t show anydistinguishable anodic peak in the potential range 0 0 1 1 V vs SCE but in the presence of captopril proportionate concentration of it the anodic peak current of chlorpromazine enhanced Under the optimizedconditions the catalytic oxidation peak current of captopril was linearly depend on the its concentration andallows the determination of captopril over the concentration range of 8 0 10 6 1 0 10 3 M captopril at pH5 0 with a detection limit LOD of 4 9 10 6 M The relative standard deviation RSD of 0 66 for thedetermination of 4 0 10 4 M captopril solution in 9 repeated measurements The chronoamperometry wasused to determine the catalytic rate constant and diffusion coefficient for the catalytic reaction ofchlorpromazine with captopril The influence of potential interfering substances on the determination ofcaptopril were studied The method was satisfactorily applied to the determination of captopril in commercialcaptopril tablets and urine samples In the second part of this project oxidation of benserazide and levodopa have been studied at modifiedcarbon paste electrode with chloranil as a heterogeneous mediator using electrochemical impedancespectroscopy cyclic and linear sweep voltammetry and chronoamperometry as diagnostic and measurementtechniques Cyclic voltammetric measurements showed that the catalytic current of the system depends onthe concentration of the drugs Under the optimized conditions the calibration curves were linear in theconcentration range of 3 0 10 5 1 0 10 4 M and 1 0 10 4 3 2 10 3 M for benserazide with a LOD5 9 10 6 M and 5 0 10 5 1 0 10 4 M and 1 0 10 4 5 0 10 3 M for levodopa with a LOD of 4 7 10 6 M The relative standard deviation for 5 0 10 5 and 2 0 10 4 M benserazide and 5 0 10 4 M levodopa were 2 0 1 5 and 2 0 respectively The chronoamperometry was used to determine the catalytic rate constant anddiffusion coefficient for the catalytic reaction of chloranil with benserazide The proposed method was usedfor the determination of benserazide and levodopa in human urine Keywords Voltammetry Electrochemical Impedance Spectroscopy Captopril Benserazide Levodopa Chlorpromazine Chloranil
استاد راهنما :
علي اصغر انصافي، تقي خياميان
استاد داور :
محمد سراجي، محمد تقي جعفري
