4512

4246

كارشناسي ارشد

شيمي آلي

اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي

1387

دوازده، 108، [II] ص: جدول، نمودار

ص.ع به فارسي و انگليسي

عبدالرضا حاجي پور

كاظم كرمي

10/3/1388

امير عبدالمالكي، حسين چيني فروشان

شيمي

ID4246

به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي

Application of amino acid and ionic liquids as chiral reaction medium and using in rapid reduction of prochiral keton s to optically active alcohols Synthesis and characterization of novel optically active poly ester imide salen s derived from inorganic complex of bis 4 Salisilidine aminophenol copper II and some different optically active diacid imide and survey of these novel coordination polymers properties Hamidreza Ahmadian Email address hamidrezaahmadian @ yahoo com April 8 2009 Department of Chemistry Isfahan University of Technology Isfahan 84156 83111 Iran Degree M Sc Language Farsi Abdol reza Hajipour Email address haji@cc iut ac ir A R Hajipour Abstract Asymmetric synthesis is one of way to synthesis of drugs and biologically compounds Different drugs have beensynthesized with this method for example Thalidomide was synthesized for treatment of morning seek phenomenon Thiscompound was synthesized in racemic mixture has a bad side effect in Childs that their mothers used this drug This drughas two enantiomers one of them has drug effect and the other have side effect Hence the importances of asymmetricsynthesis are being characterized In this thesis according to asymmetric synthesis we were synthesized some opticallyactive compound at first project by using of L alanine and BMIM Br catalytic system prepare an chiral reactionmedium We could synthesis secondary alcohols by reduction of prochiral ketones in our reaction medium in presence ofNaBH4 with low to moderate enantiomeric excess Amino acids are not soluble in most organic solvents but soluble inionic liquids We were used dissolved amino acid in ionic liquid and preparation a homogeneous catalytic medium Amino acid in this system has chiral inducement rule In the second and third projects by changing synthesis method wewere trying to preparation of a catalytic solid state containing optical active polymers with oxidative effect We couldsynthesize two types of these coordination polymers At first we synthesized a complex of copper II This complex inpresence of H2O2 converted sulfides to sulfoxides Then some chiral di acide imide prepared by combination of somedianhydride and amino acids At the end these two organic and inorganic monomers have been polymerized in catalyticsystem of pyridine and thionyl chloride These poly ester Imide Salen s are able to oxidation of some organiccompounds such as sulfides Key words Asymmetric synthesis Reduction of prochiral ketones Poly Ester Imide Salen s Chiral reaction medium

عبدالرضا حاجي پور

كاظم كرمي

امير عبدالمالكي، حسين چيني فروشان