پديد آورنده :
مجيدي، نجمه
عنوان :
ساخت حسگرهاي شيميايي و زيستي براي تعيين داروها و گونه هاي بيولوژيكي و استفاده از نانو ذرات جهت افزايش كارايي آنها
گرايش تحصيلي :
شيمي تجزيه
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي
صفحه شمار :
بيست،121ص.: مصور،جدول،نمودار
يادداشت :
ص.ع.به فارسي و انگليسي
استاد راهنما :
بهزاد رضايي
استاد مشاور :
تقي خياميان، حميدرضا رحماني
توصيفگر ها :
نانو مواد , پليمرهاي داراي قالب مولكولي , تركيبات زيستي
تاريخ نمايه سازي :
18/11/89
استاد داور :
علي اصغر انصافي، محمد كاظم اميني، ابوالفضل كياني
كد ايرانداك :
ID350 دكتري
چكيده فارسي :
به فارسي انگليسي: قابل رويت د نسخه ديجيتال
چكيده انگليسي :
1 The fabrication of chemical sensors and biosensors to assay pharmaceutical and biological analytes and the application of nanoparticles to enhance their efficiency Najme Majidi Majidi@ch iut ac ir Date of submission 15 01 2011 Department of Chemistry Isfahan University of technology Isfahan 84156 83111 IranSupervisor Name Prof Behzad Rezaei rezaei@cc iut ac irAdvisor s Name Prof Taghi KhayamianAdvisor s Name Dr Hamid Reza RahmaniDepartment Graduate Program Coordinator Prof Bijan NajafiDepartment of Chemistry Isfahan University of technology Isfahan 84156 83111 IranAbstract The capability of carbon nanotubes to have synergistic effect on the bioavailability of artemisinin wasinvestigated The uptake of drug molecules from a solution into carbon nanotubes CNTs will be achievedadsorption of 88 7 of artemisinin onto CNTs surface without alteration in drug properties The MTT assayson K562 cancer cell lines proved that CNTs enhance the anticancerous effect of artemisinin The interactionbetween artemisinin and DNA was also studied A sensitive impedimetric immunosensor was developed for determination of human growth hormone hGH and insulin like growth factor 1 IGF 1 A selective molecularly imprinted polymer MIP was synthesized for isoxicam pre concentration followed by its spectrophotometric determination A new MIP CNT modified carbon paste electrode was proposed for the square wave voltammetricdetermination of rutin Key words Multi walled carbon nanotubes MTT assay Impedimetric immunosensor Molecularly imprintedpolymer square wave voltammetry DNA Introduction Artemisinin kills cancer cells under in vivo conditions Woerdenbag et al 1993 However as artemisinin is chemically unstable and has low bioavailability therefore greaternumber of injections is necessary because of the short duration effect It would therefore bedesirable to develop methods to directly target infected cells without affecting normal ones Within the family of nanomaterials CNTs are increasingly drawing attention The aim ofthis work was to evaluate the possibility of the application of CNTs for delivery ofartemisinin and enhancing its cyto toxicity to cancerous cells Then the bioactivity ofartemisnin was assayed by its damaging effect on DNA Growth hormone GH is one of the most important index proteins in the human bodywhich its level in blood reveals growth status Giustina et al 1998 In addition it has a keyrole effect on protein lipid and carbohydrate metabolism and has recently been known as ananti aging agent Growth hormone is commonly used to treat pathologically short stature inchildren to enhance athletic performance Since the growth hormone deficiency or excessvalue has great effect on normal physiology therefore introducing a selective and specifictechnique for determination of its level in biological samples is crucial for regular clinicaltests
استاد راهنما :
بهزاد رضايي
استاد مشاور :
تقي خياميان، حميدرضا رحماني
استاد داور :
علي اصغر انصافي، محمد كاظم اميني، ابوالفضل كياني
