پديد آورنده :
مهديخاني نهر خلجي، مهدي
عنوان :
تهيه، مشخصه يابي و ارزيابي پوشش نانو كامپوزيت تخريب پذير و ضد باكتريايي پلي لاكتيك-كو-گلايكوليك اسيد- هيدروكسي آپاتيت-شيشه زيست فعال براي كاشتني هاي دنداني و ارتوپدي
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده مواد
صفحه شمار :
چهارده،171ص.: مصور[بخش رنگي]،جدول،نمودار
يادداشت :
ص.ع.به فارسي و انگليسي
استاد راهنما :
محمد حسين فتحي، وجيه السادات مرتضوي
استاد مشاور :
بهروز موسوي، محمد رضوي، بتول هاشمي بني
تاريخ نمايه سازي :
16/5/90
استاد داور :
اميد صوابي، شهناز رضوي، سعيد كرباسي
كد ايرانداك :
ID372 دكتري
چكيده فارسي :
به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي
چكيده انگليسي :
186 Preparation Characterization and Evaluation of Biodegradable and Antibacterial Ploy lactide co glycolide Hydroxyapatite Bioactive glass Nanocomposite Coating for Dental and Orthopedic Implants Mehdi Mehdikhani Nahrkhalaji me mehdikhani@gmail com June 08 2011 Department of Materials Engineering Isfahan University of Technology Isfahan 84156 83111 Iran Isfahan University of Medical Sciences Isfahan 8174673461 Iran st Mohammad Hossein Fathi 1 Fathimh@ymail com 1 Supervisor 2nd Supervisor Vajihesadat Mortazavi v mortazavi@dnt mui ac ir 1st Advisor Sayad Behrouz Mousavi2 mousavi@dnt mui ac ir 2st Advisor Sayad Mohammad Razavi3 m razavi@dnt mui ac ir 3st Advisor Batol Hashemi Beni4 hashemibeni@med mui ac irAbstractThe aim of this research was the preparation characterization and evaluation of biodegradable andantibacterial poly lactide co glycolide hydroxyapatite bioactive glass PLGA HA BG nanocompositecoating for dental and orthopedic implants Three types of bioactive glass nanoparticles with differentcompositions 58S 63S and 72S were synthesized via sol gel technique Antibacterial activity against fouraerobic bacteria and cytotoxicity of the bioactive glass nanoparticles were evaluated Subcutaneousconnective tissue reactions of rats to the bioactive glass nanoparticles and their bioactivity were evaluated Three types of nanocomposite coatings PLGA HA BG PLGA HA and PLGA BG were prepared InPLGA HA BG nanocomposite coating equal amounts of HA and BG nanoparticles was used Scanningelectron microscopy SEM Energy dispersive spectroscopy EDS XRD and Atomic force microscopy AFM were used to characterize the coatings Adipose derived stem cells adhesion viability andproliferation on the coatings were evaluated via MTT assay Degradation and bioactivity of thenanocomposite coatings were evaluated Nanocomposite coatings adhesion to Kirschner wires K wires wasevaluated in vivo Based on the results 58S and 63S bioactive glass nanoparticles showed more bioactivitythan 72S bioactive glass nanoparticles 58S composition showed the most antibacterial activity Bioactiveglass nanoparticles showed no cytotoxicity and 58S and 72S compositions induced more cell proliferation Invivo test indicated that the tissue suffers the nanoparticles PLGA could not entrap the nanoparticles inconcentrations more than 10 wt 15 and 20 wt Coatings showed no cytotoxicity and PLGA HA BG andPLGA BG nanocomposite coatings induced adhesion and proliferation of the cells In vitro degradation studyshowed the entire degradation of the coatings at about two months Apatite formation on the nanocompositecoatings with good cell response was well observed Evaluation of nanocomposite coatings adhesion on k wires showed that they remained stable on the implants at about 96 of the original coatings mass 1 Professor Biomaterials Group Department of Materials Engineering Isfahan University of Technology Isfahan 8415683111 Iran Professor Department of Operative Dentistry and Torabinejad Dental Research Center School of Dentistry Isfahan University of Medical Sciences Isfahan 8174673461 Iran 2 Professor Department of Endodontics and Torabinejad Dental Research Center School of Dentistry Isfahan University of Medical Sciences Isfahan 8174673461 Iran 3 Associate Professor Department of Oral Maxillofacial Pathology and Torabinejad Dental Research Center School of Dentistry Isfahan University of Medical Sciences Isfahan 8174673461 Iran 4 Assistant Professor Department of Anatomical Sciences School of Medicine Isfahan University of Medical Sciences Isfahan 8174673461 Iran
استاد راهنما :
محمد حسين فتحي، وجيه السادات مرتضوي
استاد مشاور :
بهروز موسوي، محمد رضوي، بتول هاشمي بني
استاد داور :
اميد صوابي، شهناز رضوي، سعيد كرباسي
