پديد آورنده :
حاج علي اكبري بيدگلي، علي اكبر
عنوان :
توسعه روش هاي ريز استخراج فاز مايع و استفاده از جاذبي جديد براي ريز استخراج فاز جامد به منظور اندازه گيري آفت كش ها و داروها در نمونه هاي زيست محيطي و زيست شناختي
گرايش تحصيلي :
شيمي تجزيه
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي
صفحه شمار :
بيست و يك،[188]ص.: مصور،جدول،نمودار
يادداشت :
ص.ع.به فارسي و انگليسي
استاد راهنما :
محمد سراجي
استاد مشاور :
علي اصغر انصافي، تقي خياميان
توصيفگر ها :
كروماتوگرافي مايع , تزريق در جريان پيوسته , طيف سنجي تحرك يوني , ولتامتري پالس تفاضلي , علف كش هاي فنيل اوره , فنازوپيريدين , كلرپرومازين
تاريخ نمايه سازي :
6/3/91
استاد داور :
حبيب باقري، مرتضي طالبي،محمدتقي جعفري
كد ايرانداك :
ID430 دكتري
چكيده فارسي :
به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي
چكيده انگليسي :
Development of Liquid Phase Microextraction Methods and Use of a Novel Solid phase Microextraction Sorbent for the Determination of Pesticides and Pharmaceuticals in Environmental and Biological Samples Ali Akbar Hajialiakbari Bidgoli E Mail bidgol1@yahoo com March 1 2012 Department of Chemistry Isfahan University of Technology 84156 83111 Isfahan IranSupervisor Associated Professor M Saraji E Mail address Saraji@cc iut ac irAdvisors Professor A A Ensafi and Professor T KhayamianDepartment Graduate Program Coordinator Professor B NajafiDepartment of Chemistry Isfahan University of Technology Isfahan 84156 83111 Iran Tel 98 311 3912369 Fax 98 311 3912350Abstract In this thesis some developed and novel liquid and solid phase microextraction methods combined withvarious determination and separation techniques high performance liquid chromatography flow injection ionmobility spectrometry and differential pulse voltammetry were used for the determination of some pesticides andpharmaceuticals In the first part surfactant assisted dispersive liquid liquid microextraction combined with highperformance liquid chromatography diode array detector was applied for the extraction and determination ofphenylurea herbicides Tebuthiuron fluometuron diuron propanil siduron linuron and diflubenzuron in theenvironmental water samples In order to obtain optimum microextraction conditions several parametersaffecting on the extraction efficiency such as extraction solvent type amount of surfactant in the extractionsolvent sedimented phase volume salt addition and time of the extraction were studied Under the optimumconditions extracting solvent chloroform amount of surfactant in chloroform 5 v v sedimented phasevolume 40 L without salt addition the procedure showed limits of detection ranging from 2 3 to 18 ng L andprecision ranges from 0 6 to 2 0 as intra day relative standard deviation RSD and from 1 3 to 8 3 asinter day RSD depending on the analyte The method showed good linearity between 0 04 and 40 g L withsquared correlation coefficients better than 0 9920 As a result the proposed method was used for analysis ofspiked real samples such as tap ground and river Zayandeh rood water samples In the second part the hollow fiber based liquid liquid liquid microextraction HF LLLME followed byflow injection analysis and diode array detection FIA DAD was applied as a simple and sensitive quantitativemethod for the determination of phenazopyridine in urine and plasma samples Flow injection system included aconventional HPLC system without a chromatographic column and a diode array detector The extraction ofphenazopyridine was carried out using diphenyl ether as the organic phase for filling the pores of the hollow fiberwall and 0 1 M H2SO4 solution as acceptor phase in the lumen of the fiber The factors affecting the HF LLLMEand flow injection analysis including type of organic solvent pH of donor phase extraction temperature extraction time stirring rate and pH of mobile phase were investigated and the optimal extraction conditionswere established With the consumption of 5 mL of sample solution the enrichment factor was about 230 Thelimit of detection was 0 5 mg L with inter and intra day precision being 6 9 and 4 9 RSD respectively Excellent linearity was found between 5 and 200 mg L Finally the HF LLLME FIA was used for the analysis ofspiked human urine and plasma samples In the third part a novel and sensitive method based on combination of two immiscible organic solventshollow fiber based liquid liquid liquid microextraction and corona discharge ion mobility spectrometry HF LLLME CD IMS was presented for the analysis of clomipramine in human urine and plasma samples
استاد راهنما :
محمد سراجي
استاد مشاور :
علي اصغر انصافي، تقي خياميان
استاد داور :
حبيب باقري، مرتضي طالبي،محمدتقي جعفري
