پديد آورنده :
زرگر خرازي، انوشه
عنوان :
طراحي، ساخت و مشخصه يابي كامپوزيت پلي لاكتيك اسيد/شيشه زيست فعال جهت استفاده در شكستگي استخوان ظريف
گرايش تحصيلي :
تخصصي بيومواد
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده مواد
صفحه شمار :
چهارده،131ص.: مصور،جدول،نمودار
يادداشت :
ص.ع.به فارسي و انگليسي
استاد راهنما :
محمدحسين فتحي، فرود بهمني
استاد مشاور :
حسين فانيان، محمدعلي ايران نژاد
توصيفگر ها :
پلاك استخواني , پلي ال-لاكتيك اسيد , تخريب پذير , فصل مشترك
تاريخ نمايه سازي :
6/3/91
استاد داور :
علي زادهوش، سعيد حصاركي، شهناز رضوي
كد ايرانداك :
ID433 دكتري
چكيده فارسي :
به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي
چكيده انگليسي :
132 Design Manufacture and Characterization of Poly lactic acid Bioactive glass for Use as Mini Plate Anousheh Zargar Kharazi a zargar@ma iut ac ir February 22 2012 Department of Materials Engineering Isfahan University of Technology Isfahan 8415683111 Iran Isfahan University of Medical Sciences Isfahan 8174673461 Iran1st Supervisor Mohammad Hosein Fathi176 fathi@cc iut ac ir2nd Supervisor Forood Bahmani bahmani@cc mui ac ir1st Advisor Hosein Fanian 2nd Advisor Mohammad Ali Iran Nejad Department Graduated Coordinator Masoud Panjepour AbstractIn this research a partially resorbable composite bone plate consisting of a poly L Lactic acidmatrix and braided textile bioglass fibers PLLA BG used as reinforcement was modeled andanalyzed using the ANSYS software V 10 0 to optimize volume fraction Vf of the reinforcement Then the PLLA BG composite samples were fabricated according to results obtained by finiteelement analysis FEA Finally a composite bone plate was manufacture similar to OsteosynthesisCo standard bone plates In order to control degradation rate of the PLLA BG composite theinterface bonding between matrix and reinforcement was improved by using Aminopropyl silanecoupling agent Moreover hot press process was selected to obtain a uniform structure with highcrystallinity and less voids content The initial mechanical properties of the composite sampleswere determined and effect of hydrolysis on the physical and mechanical properties wasconsidered Bioactivity of the composite samples was also studied Cell response to the PLLA BGsamples was assessed by using MTT assay on the human Osteoblast cells FEA Results showedthat for a volume fraction equal to 45 the longitudinal modulus of elasticity would be 23GPa thatis near to the longitudinal elastic modulus of cortical bone There was a good agreement betweenFEA and experimental results Initial value of bending modulus and bending strength of thecomposite samples yielded acceptable values similar to those of the cortical bone Moreoverdegradation process of the composite was controlled properly Strength of the treated compositedecreased only about 5 through 2 weeks and about 35 after 8weeks Although calcium phosphate formation on the surface of the composite was postponed in the treated samples thebioactivity of the composite remained unchanged and bone like apatite was formed on thecomposite surface which is important for the application of the composite in bone tissueenvironment A proper cell proliferation was observed for the Osteoblast cells in contact with thetreated composite samples It may be concluded that the PLLA BG braided composite is a goodcandidate for load bearing orthopedic applications Key words degradation rate control mechanical properties composite bone plate Professor Department of Materials Engineering Isfahan University of Technology Isfahan Iran Assistant Professor School of Medicine Isfahan University of Medical Sciences Isfahan Iran Assistant Professor School of Medicine Isfahan University of Medical Sciences Isfahan Iran Assistant Professor School of Medicine Isfahan University of Medical Sciences Isfahan Iran Assistant Professor Department of Materials Engineering Isfahan University of Technology Isfahan Iran
استاد راهنما :
محمدحسين فتحي، فرود بهمني
استاد مشاور :
حسين فانيان، محمدعلي ايران نژاد
استاد داور :
علي زادهوش، سعيد حصاركي، شهناز رضوي
