پديد آورنده :
كامفيروزي، محمد
عنوان :
استخراج گزينشي و اندازه گيري داروي پيوگليتازون در پلاسماي گاو با روش پليمر حكاكي شده ي مولكولي- اسپكترومتروي تحرك يوني با منبع يونيزاسيون الكترواسپري
مقطع تحصيلي :
كارشناسي ارشد
گرايش تحصيلي :
شيمي تجزيه
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي
صفحه شمار :
چهارده، 82ص.: مصور، جدول، نمودار
يادداشت :
ص.ع. به فارسي و انگليسي
استاد راهنما :
محمدتقي جعفري
تاريخ نمايه سازي :
31/4/91
استاد داور :
تقي خياميان، محمد سراجي
تاريخ ورود اطلاعات :
1396/09/14
چكيده فارسي :
به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي
چكيده انگليسي :
Selective Extraction and Determination of Pioglitazone Drug in Cow Plasma by Molecularly Imprinted Polymer Electrospray Ionization Ion Mobility Spectrometry Mohammad Kamfiroozi Februry 13 2012 Department of Chemistry Isfahan University of Technology Isfahan 84156 83111 Iran Degree M Sc Language Farsi Supervisor Mohammad Taghi Jafari E mail Jafari@cc iut ac ir Abstract In this study the capability of electrospray ionization ion mobility spectrometry ESI IMS was investigated for detecting and measuring of pioglitazone as an anti diabetic drug In this regard pioglitazone was analyzed by ESI IMS in both positive and negative modes of IMS The obtained low detection limits for positive and negative modes were 20 and 8 ng mL for the determination of pioglitazone In this work molecularly imprinted polymer MIP was used for extraction of pioglitazone from the cow plasma Methacrylic acid as a functional monomer ethylene glycol dimethylacrylat as cross linker 2 2 azobis 2 methyl propionitrile as an initiator and pioglitazone as a template molecule were employed to preparation of non covalent MIP adsorbent polymer with selective operation Based on the results obtained in this work MIP IMS system can be used as a powerful technique for separation pre concentration and detection of Pioglitazone drug in cow serum samples The method is exhaustively validated in terms of sensitivity selectivity recovery reproducibility and column capacity The linear dynamic ranges of 0 10 20 00 g mL and 0 02 2 00 g ml were obtained for the determination of Pioglitazone with positive and negative modes of IMS respectively The recovery of analyzed drug was calculated to be above 88 and the relative standard deviation RSD was lower than 6 for all experiments Various real samples were analyzed with the coupled techniques and the results obtained revealed the efficient clean up of the samples using MIP separation before the analysis by IMS as a detection technique Keywords Molecularly imprinted polymer Ion mobility spectrometer Electrospray ionization source Pioglitazone drug
استاد راهنما :
محمدتقي جعفري
استاد داور :
تقي خياميان، محمد سراجي
