پديد آورنده :
اثني عشري، محمد حسين
عنوان :
ساخت فلوئورهيدروكسي آپاتيت بالك نانو ساختار با استفاده از نانو پودر و بررسي تاثير ميزان يون فلوئور بر خواص مكانيكي و زيستي
مقطع تحصيلي :
كارشناسي ارشد
گرايش تحصيلي :
شناسايي و انتخاب ساخت مواد
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده مواد
صفحه شمار :
سيزده، 102ص.: مصور، جدول، نمودار
يادداشت :
ص.ع. به فارسي و انگليسي
استاد راهنما :
محمد حسين فتحي، مهدي احمديان
توصيفگر ها :
بيوسراميك , فلوئور آپاتيت , تف جوشي دو مرحله اي , زيست سازگاري
تاريخ نمايه سازي :
10/8/91
استاد داور :
محمدحسن عباسي، محمدرضا سائري
تاريخ ورود اطلاعات :
1396/09/20
چكيده فارسي :
به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي
چكيده انگليسي :
Preparation of Nanostructured Fluoridated Hydroxyapatite Bulk and Evaluation of the Effect of Fluorine Ion Content on Mechanical and Bio Properties Mohammad Hossein Esnaashary mh esnaashary@yahoo com 16 April 2012 Biomaterials Research Group Department of Materials Engineering Isfahan University of Technology Isfahan 84156 83111 IranDegree M Sc Language FarsiSupervisors Mohammad Hossein Fathi Professor fathi@cc iut ac irMahdi Ahmadian Assistant Professor ahmadian@cc iut ac irAbstractHydroxyapatite HA as a suitable substitutable material for injured bones attracted much attention becauseof its chemical and structural similarities to the natural hard tissues The fluorine F is one of the ioniccontaminations of biological HA Addition of F to HA bioceramic increases thermal and chemical stability and improves mechanical properties when sintered at high temperatures Furthermore F stimulates cellattachment proliferation and differentiation Nanostructured bulk of fluoridated hydroxyapatite FHA issignificant for bone tissue regeneration This material as compared to coarser grain size bulks promotesmechanical properties and biological responses Therefore the aim of this work was to fabricatenanostructured FHA bulk via the two step sintering TSS process Different parameters of the TSS processsuch as initial and secondary temperatures T1 and T2 initial and secondary holding times t1 and t2 andcompaction pressure P were assessed via the Taguchi method In addition the effect of F content onsinterability and mechanical properties of FHA was studied Phase structure morphology and structure andfunctional groups of prepared FHA were characterized using X ray diffraction XRD Scanning ElectronMicroscopy SEM and Fourier Transform Infrared spectroscopy FT IR techniques Mechanical propertieswere determined by a microhardness tester and biological properties were evaluated by pH variation and ionreleasing in simulated body fluid P T1 t1 and T2 had the highest effect on consolidation respectively Mono phased FHA bulk with high density were produced at 1000 C 900 C 10 min 24 hours and 200 MPa forT1 T2 t1 t2 and P respectively which optimized by Taguchi method The average crystallite sizes ofproduced FHA were estimated to be 105 nm By increasing the F content the sinterability of FHA bulks wasdecreased and densification was delayed In addition hardness increased and fracture toughness decreased asF content increased Biological evaluation indicated bone like apatite nucleation and growth on the surface ofprepared nanobioceramics Furthermore the sintered FHA not only didn t show any cytotoxicity effect onHuman osteoblast cells although increased their proliferation As F content increased Human osteoblastcells proliferation rate a little decreased since the amount of released calcium in the culture mediumdecreased Therefore due to the mechanical and biological improvement fabricated nanostructured FHAcould be a potential candidate for unloaded bone tissue regeneration applications Keywords Bioceramic Fluorapatite Hydroxyapatite Two Step Sintering Nanostructure Biocompatibility
استاد راهنما :
محمد حسين فتحي، مهدي احمديان
استاد داور :
محمدحسن عباسي، محمدرضا سائري
