7201

6707

كارشناسي ارشد

شناسايي و انتخاب و روش ساخت مواد

اصفهان: دانشگاه صنعتي اصفهان، دانشكده مواد

1391

ده، 117ص.: مصور، جدول، نمودار

ص.ع. به فارسي و انگليسي

محمدحسين فتحي، علي سعيدي

10/8/91

محمدعلي گلعذار، محمدرضا سائري

1396/09/20

كتابنامه

مواد

مهندسي مواد

ID6707

به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي

Fabrication and Characterization of Beta Tricalcium Phosphate Forsterite Nanocomposite Foam Parsa Rezvanian Parsa Rezvanian@gmail com Date of Submission 12th May 2012 Department of Materials Engineering Isfahan University of Technology Isfahan 84156 83111 IranDegree M Sc Language FarsiSupervisorsM H Fathi Fathi@cc iut ac irA Saeidi A saidi@cc iut ac irAbstractDue to their biodegradation characteristics similarity in composition with natural bone tissue and highbiocompatibility porous Beta Tricalcium Phosphate TCP ceramics are widely used in bone tissuereplacement Due to its excellent properties like high fracture toughness Forsterite is a proper substitute forhydroxyapatite Because of their improved properties such as grain size and surface energy Forsterite nanoceramic unlike micron sized Forsterite is bioactive and is able to form apatite in simulated body fluid andincrease osteoblast adhesion proliferation and osteointegration thus guarantee prolonged life for the implant Inthis study beta tricalcium phosphate forsterite nano composite foams for tissue engineering applications werefabricated TCP and forsterite nano powders were fabricated using sol gel and mechanical activationmethods respectively With adding 0 5 15 and 25 wt forsterite to TCP beta tricalcium phosphate forsterite nano composite foams were fabricated using gel casting method X ray Diffraction XRD analysiswas used for structural and phase evaluation of foams Scanning Electron Microscope SEM was used todetermine pore size and morphology To determine the grain size of synthesized powders and foams TransitionElectron Microscope TEM was used Compresion Test was used to determine mechanical properties of thefoams In order to evaluate the bioactivity and biodegradation the foams were soaked in simulated body fluid SBF for 28 days Scanning electron microscope SEM was used to evaluate the apatite layer formation in thepores To determine the dissolution level of Calcium Phosphorous and Magnesium ions and biodegradability offoams in SBF Inductively Coupled Plasma Optical Emission Spectrometry ICP OES analysis was used Results confirmed the successful fabrication of nano composite foams Prepared foams possess 70 80 porosity with the mean pore size of 200 600 m and grain size of about 60 nanometers The results showed thatby increasing wt of forsterite in foams the mechanical properties also increased Compression strengthincreased from 0 94 MPa for TCP foam to 1 77 MPa for foam containing 25 wt forsterite In Vitrobioactivity tests proved that the foams are bioactive and after soaking in SBF bone like apatite was formed onthe surface of the foams It was concluded that biodegradation of the foams can be controlled with changing TCP to Forsterite ratio According to the results these foams can be a suitable candidate for bone tissueengineering and drug delivery applications Keywords Forsterite Tricalcium Phosphate Nanostructure Nanocomposite TissueEngineering Bone Scaffold Gel Casting Foam

محمدحسين فتحي، علي سعيدي

محمدعلي گلعذار، محمدرضا سائري