7314

6820

كارشناسي ارشد

شيمي تجزيه

اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي

1391

نه، 74ص.: مصور، جدول، نمودار

ص.ع. به فارسي و انگليسي

محمدتقي جعقري، محمد سراجي

28/8/91

تقي خياميان، بهزاد رضايي

1396/09/21

كتابنامه

شيمي

شيمي

ID6820

به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي

۷۳ Hollow Fiber based Liquid Liquid Liquid Microextraction Combined with Electrospray Ionization Ion Mobility Spectrometry ESI IMS for the Determination of Propranolol in Biological Samples Mehrnoush Jalil m jalil@ch iut ac ir August11 2012 Department of Chemistry IsfahanUniversity of Technologhy Isfahan 84156 83111 Iran Degree M Sc Language Farsi Supervisors Assis Prof Mohammad Taghi Jafari jafari@cc iut ac ir Assoc Prof Mohammad Saraji saraji@cc iut ac ir Abstract In this research coupling of hollow fiber based liquid liquid liquid microextraction HF LLLME method and ESI IMS was used for preconcentration and determination of Propranolol in biological samplesincluding urine and plasma For finding better efficiency the three phase LPME by Acetic Acid acceptorphase and the three phase LPME by MeOH acceptor phase were be tested In hollow fiber based liquid liquid liquid microextraction a layer of organic phase is impregnated into the pores of a porous hollow fiber while the lumen of the hollow fiber was filled with CH3COOH 0 5 M solution as an acceptor solution thatwas connected directly to the needle of a microsyringe The fiber was then immersed into 3 ml of a basicaqueous sample Effective parameters on HF LLLME such as solvent type pH of donor phase acidity ofacceptor phase sample stirring rate salt addition extraction temperature and extraction time were studied The extraction efficiency of HF LPME by Acetic Acid Acceptor was achieved utilizing a 1 3 cm poroushollow fiber immobilized with Isoamylbenzoate 0 001M NaOH 3 mL donor phase sample without NaCladdition 0 005 M CH3COOH solution as acceptor phase 1000 rpm stirring rate and 20 min extraction timeat room temperature The analyte was extracted quantitatively from the sample solution into the acceptorsolution with an enrichment factor 40 The limit of detection of the method was 1 6 g L CorrelationCoefficient was 0 991 and inter and intra relative standard deviation were 6 and 12 respectively The extraction efficiency of HF LPME by MeOH Acceptor was achieved utilizing a 4 cm poroushollow fiber immobilized with n dodecane 0 001M NaOH 3 mL donor phase sample without NaCladdition 0 0005 M CH3COOH solution as acceptor phase 1200 rpm stirring rate and 15 min extraction timeat room temperature The analyte was extracted quantitatively from the sample solution into the acceptorsolution with an enrichment factor 21 The limit of detection of the method was 1 76 g L The CorrelationCoefficient was 0 993 and relative standard deviation in a day was 7 and between days was 5 Resultsshow that microextractions with Acetic acid and MeOH acceptors have same Limit of Detection linearrange The enrichment factor for acetic acid acceptor was 40 and for MeOH was equal to 21 Not requiring todilution MeOH Acceptor is faster Keywords Liquid Liquid Liquid Microextraction Hollow Fiber Based Microextraction by Acetic Acid Acceptor Hollow Fiber Based Microextraction by MeOH Acceptor Propranolol on Mobility Spectrometry

محمدتقي جعقري، محمد سراجي

تقي خياميان، بهزاد رضايي