7344

6852

كارشناسي ارشد

فيزيك

اصفهان: دانشگاه صنعتي اصفهان، دانشكده فيزيك

1391

نوزده، 142ص.: مصور، جدول، نمودار

ص.ع. به فارسي و انگليسي

ظفرا... كلانتري، حسين خلفي

اكبر پروازيان

11/9/91

احمد شيراني، محمدحسن علامت ساز

1396/09/21

كتابنامه

فيزيك

فيزيك

ID6852

به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي

Feasibility Study of Using Laser Electron Accelerator as a Neutron Source for BNCT Nafiseh Sadat Hoseyni n hoseyni@ph iut ac ir Date of Submission 2012 07 14 Department of physics Isfahan University of Technology Isfahan 84156 83111 Iran Degree M Sc Language FarsiSupervisor Dr Syed Zafarollah Kalantari zafar@cc iut ac irAbstractBoron neutron capture therapy is a new method in the treatment of brain tumors In this method after injecting ofthe boron carrier drug and its absorption in the tumor cells the tumor is irradiated by neutron with an appropriateintensity and energy When boron neutron capture reaction s energy is discharged in the tumor cells this energy candestruct it Up to now different neutron sources such as nuclear reactors various accelerators radioisotopes neutron generators etc have been used or studied for application in boron neutron capture therapy Today anextensive research is being done on the construction of a compact neutron source that can be installed in hospitals The most important of such neutron source is a photoneutron source based on electron linear accelerator In this typeof sources neutron is generated during the e and n process In addition to the linear accelerator Laseraccelerators that can accelerate charged particles to high energies in short distances have been under study in variousfields In this project the usage of electron laser accelerators to produce photoneutron for Boron neutron capturetherapy has been evaluated The typical laser accelerator produces 3 electrons per second with average energyof 170 MeV In order to assess the feasibility of using this accelerator in the boron neutron capture therapy anappropriate target for photoneutron production was designed and optimized in terms of material and geometry Various materials were examined such as lead bismuth tantalum and tungsten with cylindrical spherical andhemispheres geometries Produced neutrons have a wide energy range which are typically not suitable for treatmentand need to be optimized in terms of intensity and energy therefore a beam shaping assembly was designed andoptimized that is inclusive moderator reflector collimator and filters Optimization criteria were considered toachieve the epithermal neutron beam with the lowest thermal and fast neutrons and gamma rays contamination Optimal design includes 80cm of fluental as a moderator 20cm lead as a reflector 0 1cm bismuth as a gamma filterand 1 5 cm lithium 6 as a thermal neutron filter respectively In this case epithermal neutron flux of order is achieved which is far from the amount needed to treatment Final results showthat by considering the current laser technology this kind of accelerators do not have sufficient performance toproduce neutrons with a suitable intensity for BNCT but these types of sources can be used in biological researchand animal studies One can used fission plate as a neutron multiplier to increase the neutron flux in the beamshaping Assembly All stages of the production process as well as transportation of neutrons in the beam shapingassembly were simulated by the MCNPX Monte Carlo code Keywords electron Laser acceleration Photo neutron MCNPX Monte Carlo code Boron Neutron CaptureTherapy Beam shaping Assembly

ظفرا... كلانتري، حسين خلفي

اكبر پروازيان

احمد شيراني، محمدحسن علامت ساز