7485

6991

كارشناسي ارشد

ماده ي چگال

اصفهان : دانشگاه صنعتي اصفهان، دانشكده فيزيك

1391

هفت، 55ص.: مصور، نمودار

ص.ع. به فارسي و انگليسي

فرهاد فضيله

كيوان آقابابائي

7/11/91

پيمان صاحب سرا

داخلي: فرهاد شهبازي

1396/09/22

كتابنامه

فيزيك

فيزيك

ID6991

به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي

Study of the Interaction Between Influenza A Virus and Immune System Fariba Shayegani f shayegani@ph iut ac ir Date of submission 2012 09 19 Department of Physics Isfahan University of Technology Isfahan 84156 83111 Iran Degree M Sc Language Persian Supervisor Dr Farhad Fazileh fazileh@cc iut ac ir Abstract Human influenza is an infection of the upper respiratory tract and the major central airways Spanish influenza which occurs in 1918 1919 is the most famous pandemic that kill 20 40 milion people in the world Influenza transmits through aerosol small drops in talking or coughing prevention from transmission of influenza through the air is impossible so immunization is the best way for control of virus Entry of virus into the body stimulate immune response Immune system is composed of various cells that each type of cell has a special dynamics We use mathematical models and simulation methods to clarify the mechanism of interaction between virus and host cell and to obtain dynamics of viral disease These models describe how viruses spread from cell to cell One of these models is ordinary diffrential equation In this model concentration of viruses and cells are evaluated as a function of time using a system of diffrential equations Quasispecies is another model which we use it for obtaining dynamics of an infection A large number of important viruses including HIV hepatitis C and influenza have RNA genomes These viruses replicate with extremely high mutation rates and exhibit significant genetic diversity A quasispecies is a cloud of diverse variants that are genetically linked through mutation One of the simulation methods is cellular automaton A cellular automaton is a discrete model studied in computability theory mathematics and theoretical biology CA are said to be discrete because they operate in finite space and time and with properties that can have only a finite number of states In this thesis we review different models which have been applied to stimulate influenza A infection In the end we propose an algorithm which is based on a combinations of quasispecies and cellular automata approches to numerically simulate the influenza A infection Keywords Influenza A virus IAV Immune system Cellular automata Quasispecies ordinary diffrential equation ODE

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