عنوان :
كمپلكس هاي پلي پيريديلي روتنيوم ﴿II﴾ و روي ﴿II﴾; بررسي برهمكنش آنها با FS-DNA و مطالعه اثر الكتروكاتاليتيكي trans[Ru(dmb)2 Cl(EtOH)PF6 در احياء Co2به Co
مقطع تحصيلي :
كارشناسي ارشد
گرايش تحصيلي :
شيمي معدني
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي
صفحه شمار :
ده،69ص.: مصور،جدول،نمودار
يادداشت :
ص.ع.به فارسي و انگليسي
استاد راهنما :
حسن حدادزاده، مونا سليمي
استاد مشاور :
حسين فرخ پور
توصيفگر ها :
ليگاندهاي پلي پيريديلي , فعاليت نوكلئوآزي , سميت سلولي
تاريخ نمايه سازي :
20/1/92
استاد داور :
كاظم كرمي، حسين توكل
چكيده فارسي :
به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي
چكيده انگليسي :
72 Polypyridyl Ru II and Zn II complexes trans Ru dmb 2 EtOH Cl PF6 and Zn dmb 3 PF6 2 electrochemical properties and structure spectroscopic DNA binding Electrochemical reduction of CO2 to CO by trans Ru dmb 2 EtOH Cl PF6 Nafiseh Serri n serry@ch iut ac ir Date of Submission 2013 1 23 Department of Chemistry Isfahan University of Technology Isfahan 84156 83111 Iran Degree M S Language Farsi H Hadadzadeh Prof hadad@cc iut ac ir Abstract In this thesis two mononuclear complexes of Zn II and Ru II Zn dmb 3 PF6 2 and trans Ru dmb 2 EtOH Cl PF6 dmb 4 4 dimethyl 2 2 bipyridine have been prepared and characterized by elemental analysis FT IR and UV vis spectroscopies Crystal structure showed which the coordination geometry crystals of Zn dmb 3 PF6 2 around the Zn II was a distorted octahedral The dmb ligands are coordinated to Zn II ions through two nitrogen atoms Brown crystals of trans Ru dmb 2 EtOH Cl PF6 were grown by ether diffusion into a acetonitrile solution of the complex This complex was crystallized with the following unit cell parameters a 15 04 b 11 524 c 16 288 90 90 90 Z 4 and V 3 2823 1 Single crystal structure showed that the coordination geometry around the Ru II was a distorted octahedral The FT IR spectra of these complexes showed that bands are shifted and their intensity are changed in comparison with free dmb ligand The interaction of the trans Ru dmb 2 EtOH Cl PF6 and Zn dmb 3 PF6 2 complexes with DNA was investigated by UV vis and fluorescence Spectroscopies cyclic voltammetry and gel electrophoresis Absorption spectra titrations of these complexes with fish DNA suggest that these complexes bind to DNA The magnitude of the binding constant Kb was obtained from absorption spectra titration All the results showed the majority of interaction mode between the complex and DNA was electroestatic An in vitro cytotoxicity study of the Zn dmb 3 PF6 2 trans Ru dmb 2 EtOH Cl PF6 and Ru phen diox 3 PF6 2 phen diox 2 3 dihydro 4a 12b epoxyethanooxy 1 4 dioxino 2 3 f 1 10 phenanthroline complexes on human breast adenocarcinoma MCF7 cell line by an MTT assay indicated that these complexes may have anticancer potency with a cytotoxicity value of 0 96 1 69 M 0 6 1 14 M and 7 96 1 8 M respectively and DNA cleavage experiments showed plasmid DNA The electrocatalytic that these complexes induce cleavage of pTZ57 DNA reduction of CO2 to CO by trans Ru dmb 2 EtOH Cl PF6 was investigated using cyclic voltammetry in CH3CN solution Thedetailed reaction mechanism and intermediates structures for the electrocatalytic reduction were also studied with the aid of density functional theory DFT Key word Polypyridyl ligands DNA binding interaction DNA cleavage cytotoxicity activity electrocatalytic reduction Zinc II complex Ruthenium II complex PDF created with pdfFactory trial version www pdffactory com
استاد راهنما :
حسن حدادزاده، مونا سليمي
استاد مشاور :
حسين فرخ پور
استاد داور :
كاظم كرمي، حسين توكل