7918

7366

كارشناسي ارشد

شيمي تجزيه

اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي

1391

پانزده،60ص.: مصور،جدول،نمودار﴿رنگي﴾

ص.ع.به فارسي و انگليسي

علي اصغر انصافي

بهزاد رضايي

9/6/92

ساراجي،تقي خياميان

شيمي

ID7366

به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي

63 Design and preparation of highly selective coated wire potentiometric sensors for determination of Morphine sulfate and Methadone hydrochlorid in pharmaceutical compounds and in urine Marziyeh Mohamadkhani m mohamadkhani@ch iut ac ir Department of Chemistry Isfahan University of Technology Isfahan 84156 83111 Iran Degree M Sc Language Farsi Ali A Ensafi Email Ensafi@cc iut ac ir Abstract This research introduces the design of new PVC membrane electrodes for analysis of two abuse drugs In the first part of this work the construction and electrochemical response characteristics of polyvinyl chloride PVC membrane sensors for the determination of morphine is described An ion pair of morphine sodium tetraphenyl borate was used as an electroactive material and dibutyl phthalate DBP as an anion excluder in a PVC matrix in the percentage ratio of 2 60 62 51 35 10 w w This potentiometric sensor exhibits a linear response to morphine in a concentration range of 1 0 10 3 to 2 0 10 6 M with a limit of detection of 2 3 10 6 M and with a slope of 58 62 1 7mV decade 1 over the pH range 3 4 6 2 The selectivity coefficients of the sensor for morphine relative to a numbers of potential interfering compounds were investigated The sensor is highly selective for morphine over a large number of similar compounds The sensor showing a fast response time of 25 s and was used over a period of 2 month with a good reproducibility The sensor was successfully applied to determine morphine in pharmaceutical urine and blood serum samples with satisfactory results In the part two of this research a new PVC membrane sensor is described as a potentiometric sensor for methadone The sensor having methadone sodium tetra phenyl phthalate ion pair as an electro active material and dioctyl phthalate DOP as an anion excluder in PVC matrix in the percentage ratio of 2 8 64 6 32 8 ion pair DOP PVC w w The membrane sensor exhibit suitable response to methadone in a concentration range of 6 0 10 6 1 0 10 2 M with a limit of detection of 4 37 g ml The slope of the system was 59 88 1 8 mv decade Selectivity coefficient for methadone relative to a numbers of potential interfering substances were investigated The sensor was highly selective for methadone over a large number of similar compounds The sensor showing a fast response time of 20 s and was used over a period of 2 months with a good reproducibility The sensor was successfully applied to determine Methadone in real sample such as human urine tablets and other pharmaceutical product with satisfactory results Keywords Potentiometric sensor Sodium tetraphenyl borate Morphine sulfate Methadone hydrochlorid PDF created with pdfFactory trial version www pdffactory com

علي اصغر انصافي

بهزاد رضايي

ساراجي،تقي خياميان