پديد آورنده :
عباسيان، نويد
عنوان :
سنتز و شناسايي نانو ذرات BSA-PEG مطالعه ي كنترل رهايش داروي Fluorouracil-5
مقطع تحصيلي :
كارشناسي ارشد
گرايش تحصيلي :
مهندسي شيمي
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده مهندسي شيمي
صفحه شمار :
سيزده،104ص.: مصور،جدول،نمودار
يادداشت :
ص.ع.به فارسي و انگليسي
استاد راهنما :
كيقباد شمس
توصيفگر ها :
فلورويوراسيل , نانو ذرات سرم آلبومين گاوي , پلي اتيلن گلايكول
تاريخ نمايه سازي :
17/9/92
استاد داور :
نسرين اعتصامي، احمد اسدي نژاد
چكيده فارسي :
به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي
چكيده انگليسي :
Synthesis and Characterization of BSA Conjugated PEG and Investigation of Fluorouracil Controlled Release Navid Abbasian Navid abasian@yahoo com April Department of Chemical Engineering Isfahan University of Technology Isfahan Iran Degree M Sc Language Farsi Supervisor Keyghobad Shams k shams@cc iut ac ir Abstract Apart from surgery radiation and biologic therapies the therapeutic strategies presently used for cancer treatment are focused on cytotoxic drugs as the main form of chemotherapy for cancer In comparison to other drug classes cytotoxic anticancer drugs present unique problems that come primarily from the relative lack of specificity of their systemic bio distribution and the subsequent side effects provoked by the drug attacking both healthy and target cells The therapy potency of anticancer agent can be improved and its toxicity may be diminished by facilitating the specific accumulation of this anticancer agent in the tumor infected regions with prolonged exposure of the cells to this agent In this sense the immobilization of anticancer drugs to delivery systems such as nano particles has been an interesting approach to controlled release of these active agents The purpose of this project was synthesis of bovine serum albumincontaining fluorouracil coated with poly ethylene glycol dinitrophenyle carbonate and investigation of effects of coating concentration and average molecular weight of polyethylene glycol on FU release These nano particles are non toxic non immunogen biocompatible and biodegradable they have prolong circulation half life in body and are suitable for drug delivery The results of this study indicated that the concentration and the average molecular weight of PEG are the most effective factors on FU controlled release from nano particles Drug loading efficiency in nano particle was The desolvation method was used for preparation of bovine serum albumin nano particles because it is compatible with hydrophobic drugs such as FU it is simple and it does not require any special equipment The minimum and maximum diameter of nano particles was determined by PCS analysis PDF created with pdfFactory trial version www pdffactory com
استاد راهنما :
كيقباد شمس
استاد داور :
نسرين اعتصامي، احمد اسدي نژاد
