پديد آورنده :
خرازيهاي اصفهاني، مهشيد
عنوان :
طراحي، ساخت و مشخصه يابي داربست نانو كامپوزيتي ليفي پلي كاپرولاكتون- فورستريت براي كاربردهاي مهندسي بافت استخوان
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده مواد
صفحه شمار :
چهارده،148ص.: مصور،جدول،نمودار
يادداشت :
ص.ع.به فارسي و انگليسي
استاد راهنما :
محمدحسين فتحي، حسين ادريس
توصيفگر ها :
الكتروريسي , رهايش دارو
تاريخ نمايه سازي :
9/10/92
استاد داور :
سعيد نوري خراساني، شقايق حق جو جوانمرد، مهدي احمديان
كد ايرانداك :
ID595 دكتري
چكيده فارسي :
به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي
چكيده انگليسي :
Design fabrication and characterization of nanocomposite fibrous PCL Forsterite scaffolds for bone tissue engineering Mahshid Kharaziha Date of Submission 09 01 2013 Kharaziha@ma iut ac ir Department of Materials Engineering Isfahan University of Technology Isfahan 84156 83111 IranSupervisor M H Fathi Professor fathi@cc iut ac ir Supervisor H Edris Professor h edris@cc iut ac ir Department Graduate Program Coordinator K RaeissiAbstract The basic aim of this research is to develop novel nanofibrous scaffolds through electrospinning ofPCL forsterite nanopowder The scaffolds were characterized with regard to structural and mechanicalproperties degradation bioactivity and cellular interactive responses Then forsterite nanopowders wassurface modified using esterification reaction and PCL surface modified forsterite scaffolds were developed At the next step due to low hydrophilicity of synthetic polymers gelatin fibers were also added to PCL forsterite scaffolds through sequential electrospinning method and the effects of the layer by layer structureon the physical mechanical and biological properties of scaffolds were investigated Due to suitable effectsof differentiation factors on the osteogenesis and bone treatment dexamethasone was added during theelectrospinning of pure PCL and PCL forsterite scaffolds Finally the effects of forsterite nanopowder andfibrous architecture on the drug release kinetics were studied Results showed that forsterite nanopowderenhanced mechanical properties the degradation rate and bioactivity of PCL scaffold Furthermore composite nanofibrous scaffolds possessed significantly improved cellular responses in terms of attachment proliferation and mineralization of pre osteoblasts compared to PCL one Surface modification ofnanoparticles significantly enhanced the tensile strength and modulus of scaffolds compared to unmodifiedsamples respectively due to improved compatibility between matrix and filler Furthermore multilayeredscaffolds with 40 micrometer pore sizes could be obtained through subsequent electrospinning technique The addition of gelatin layer dramatically improved the hydrophilicity of PCL F scaffold while did notsignificantly change its stiffness and strength Moreover compared to pure gelatin scaffold the attachmentand proliferation of SHED cultured on the multilayered fibrous scaffolds were not significantly different Studies demonstrated that while dexamethasone release was sustained over a period of 4 weeks its kineticwas governed by the membrane architecture and composition Forsterite nanopowder inclusion as adetermining factor for drug release changed the kinetic of DEX release from Fickian diffusion to ananomalous transport Furthermore while DEX release decreased SHED proliferation stimulatedmineralization Thus the currently developed nanofibrous composite membranes embedded in forsteritenanopowder expected to be attractive in GBR membrane applications Key words Bone tissue engineering Electrospinning Forsterite Drug release 1 Introduction Guided bone regeneration GBR has been proposed as an effective therapy torepair the alveolar and mandible bone defects In this therapy a scaffold is applied to
استاد راهنما :
محمدحسين فتحي، حسين ادريس
استاد داور :
سعيد نوري خراساني، شقايق حق جو جوانمرد، مهدي احمديان
