8438

7819

كارشناسي ارشد

شيمي آلي

اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي

1392

چهارده،82ص.: مصور،جدول،نمودار

ص.ع.به فارسي و انگليسي

عبدالرضا حاجي پور

عليرضا نجفي

1/11/92

امير عبدالملكي، حسين توكل

شيمي

ID7819

به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي

Application of choline copper chloride ionic liquid as an efficient catalyst in Pd free Sonogashira reaction and application of Iron ceria zirconia and zirconium phosphates zinc catalysts in Friedel Crafts acylation Seyed Hadi Nazemzade shnazem@gmail com Department of Chemistry Isfahan University of Technology 84156 83111 Isfahan Iran Degree M Sc Language Farsi Prof A R Hajipour Email haji@cc iut ac ir Abstract Due to many vast application of C C bond formation in the areas including bioactive compounds natural products and high performance materials over the past few years the C C coupling reactions have become a versatile tool in organic synthesis One of the most efficient methods in this category is Sonogashira coupling reaction In this work the application of a new efficient and inexpensive ionic liquid copper I chlorid Cholin chlorid is studied The ionic liquid catalytic system has been developed to catalyze ligand and palladium free Sonogashira coupling reactions of phenylacetylenes with a variety of aryl halides to afford the corresponding coupling products in 18 97 yields The present catalytic system appears attractive in view of its ease of application and low cost due to the use of a readily available non noble metal catalyst combined with the absence of ligands We found that electron withdrawing and donating substituents on aryl halides enhanced the coupling of aryl halides with phenyl acetylenes Excellent yield of the Sonogashira reaction catalyzed by 20 mol ionic liquid could be achieved at 140 C and DMF as the solvent within 2 10 hours Solid state or solvent free reactions are called green or clean reactions because organic solvents are not used in these reactions In the next section Stable and non hygroscopic Fe ZrCe and Zn ZrP which are prepared easily and commercially available compounds was found to be an effective catalyst for Friedel Crafts acylation reactions using carboxylic acids acetic anhydride and benzoyl chloride in the absence of solvent under mild reaction conditions Both catalyst aromatic carboxylic acids reacted easily to afford the corresponding aromatic ketones The use of non toxic and inexpensive materials simple and clean work up short reaction times and good yields of the products are the advantages of this method For these reactions 1 H NMR 13C NMR FT IR and GC technologies were used Keywords Ionic liquid choline Chloride Sonogashira reaction Friedel Crafts acylation Ce2Zr1 5Fe0 5O8 ZrPO4Zn solvent less PDF created with pdfFactory trial version www pdffactory com

عبدالرضا حاجي پور

عليرضا نجفي

امير عبدالملكي، حسين توكل