پديد آورنده :
صادقيان رداني، زهرا
عنوان :
سنتز و شناسايي كمپلكس هاي كبالت ﴿II﴾ و روي ﴿II﴾ با ليگاند پيرازين آميد و بررسي خواص ضد باكتريايي آن ها
مقطع تحصيلي :
كارشناسي ارشد
گرايش تحصيلي :
شيمي معدني
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي
صفحه شمار :
ده،80ص.: مصور،جدول،نمودار﴿رنگي﴾
يادداشت :
ص.ع.به فارسي و انگليسي
استاد راهنما :
حسين چيني فروشان
استاد مشاور :
محمدرضا سبزعليان
توصيفگر ها :
داروهاي ضد سل , باكتري هاي گرم مثبت , باكتري هاي گرم منفي
تاريخ نمايه سازي :
12/11/92
استاد داور :
علي حسين كيانفر، غلامحسين محمدنژاد
چكيده فارسي :
به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي
چكيده انگليسي :
Synthesis and Characterization ofCo II and Zn II ComplexeswithPyrazineamide Ligand and studies the antibacterial activity of the Complexes Zahra Sadeghian Zahra Sadeghian@ch iut ac ir Date of Submission Department of Chemistry Isfahan University of Technology Isfahan Iran Degree M Sc Language Farsi Supervisor Dr HosseineChiniforoushan Email chinif@cc iut ac ir Abstract In this thesis Co II and Zn II metal complexes with thePyrazinamidemedicinal Ligandhave been synthesized in the presence of bipyridine and phenanthroline Pyrazinamide is coordinated to the metal ion through the amide oxygen and ring nitrogen Pyrazinamide a member of the Pyrazine is among the first line drugs for the treatment of tuberculosis Investigating the interaction of drugs and transition metals isan important and active research area in bioinorganic chemistry Moreover molecular complexes having PZA as ligand are shown to have enhancement antimycobacterialproperties The complexes of Co PZA L ClO Zn PZA L ClO L bipyridine or phenanthroline have been synthesized and characterized with spectroscopic methods IR UV Vis H NMR andelemental analysis The crystal structure of Co PZA bipy ClO has been determined by X ray crystallography which reveals coordination of disordered octahedral for Co II Biological studies show the antibacterial activity of the complexes against Gram positive and Gram negative bacterial strains Keywords Pyrazinamide Antibacterial activity Treatment of tuberculosis Complex Co PZA L ClO Complex Zn PZA L ClO Gram positive bacterial Gram negative bacterial PDF created with pdfFactory trial version www pdffactory com
استاد راهنما :
حسين چيني فروشان
استاد مشاور :
محمدرضا سبزعليان
استاد داور :
علي حسين كيانفر، غلامحسين محمدنژاد
