مدل سازي سنتز ميكرو به روش افزايش پراكندگي محلول با سيال فوق بحراني

چكيده انگليسي :

128 Modeling of microparticles synthesis using Solution enhanced dispersion by supercritical fluids Amir Hossein Mohamadian ah mohamadian@ce iut ac ir Date of Submission Department of Chemical Engineering Isfahan University of Technology Isfahan 84156 83111 Iran Degree M Sc Language FarsiSupervisors Seyyed Mohammad Ghoreishi ghoreshi@cc iut ac irAbstract Particle design using supercritical CO2 has been of great interest in the pharmaceutical microelectronic catalytic and related industries over the past 10 years The solubility of most drug compounds in carbon dioxideis very low making it a very attractive antisolvent for particle formation Particles from Solution enhanceddispersion by supercritical fluids SEDS is one of the supercritical antisolvent fluid techniques for nanoparticlesgeneration This process uses a coaxial nozzle design where the solvent with the solute of interest is injected inthe inner tube and the supercritical CO2 is injected in the outer tube The two streams mix in a small volumeregion of the nozzle called mixing length before exiting through the nozzle tip into a chamber maintained Thefast mixing process rapidly expands the solvent with CO2 in order to induce phase split of the solid drugparticles Main goals of this thesis were to model this process with using ANSYS FLUENT 13 software andmodel validation via comparison with experimental data Furthermore the validation model was used toinvestigate the effect of different design and operating variables on the particle size of the synthesis sizednanoparticles Moreover the parametric analysis of nanoparticle size design was carried out at the differentoperating range of effective variables In this thesis by comparing results of model with a particular experimentaldata pharmacicual nanoparticles of acetaminophen the model predicted data had 1 30 error in contrast toexperimental results The other reported models in the literature have higher error than the model of this study Thus this model was used to investigate the effect of different parameters such as pre expansion temperature pre expansion pressure and nozzle length on the average particle diameter and so we can use this model to knoweffect of dependent parameters to get profiles of thermodynamic profiles of thermodynamic properties along thenozzle and capillary Dependent on entrance conditions to nozzle average of particle diameter can be in the rangeof 0 7 20 m The obtained narrow particle size distribution is a normal Gaussian curve which coincides withexperimental data Modeling results of Particles from Solution enhanced dispersion by supercritical fluidsshowed that increasing the pre expansion temperature produced largerer particles because temperature is aneffective parameter on the growth of particles The increasing pre expansion pressure led to the synthesis oflarger particles Modeling results of SEDS showed that increasing nozzle length led to smaller particles so thatLang mixing length of nozzle is appropriate suitable design condition Keywords modeling Supercritical antisolvent fluid acetaminophen Solution enhanced dispersion bysupercritical fluids coaxial nozzle

محمديان، اميرحسين

مدل سازي سنتز ميكرو به روش افزايش پراكندگي محلول با سيال فوق بحراني

ضد حلال فوق بحراني , استامينوفن , افزايش پراكندگي محلول , نازل دو كاناله ي هم محور