10573

9756

كارشناسي ارشد

مهندسي مواد

اصفهان: دانشگاه صنعتي اصفهان، دانشكده مهندسي مواد

1394

ده، 96ص.: مصور

حسين ادريس، محمدحسين فتحي

وجيه السادات مرتضوي

1394/08/09

احمد منشي،مهشيد خرازيها

1396/10/05

كتابنامه

مواد

مهندسي مواد

ID9756

97 Synthesis and characterization of nano powder and compositefoam of tricalcium phosphate strontium fluorapatite for medical application Morteza Alehosseini m alehosseini@ma iut ac ir July 27 2015 Department of Materials Engineering Isfahan University of Technology Isfahan 84156 83111 Iran Degree MSc Language FarsiSupervisors Hossein Edris h edris@cc iut ac irMohammad Hossein Fathi fathi@cc iut ac irDepartment Graduate Coordinator Keyvan RaeissiAbstractIn tissue engineering biodegradable scaffolds are basically used to provide temporarymechanical strength and necessary ions for the growth of bone A bone scaffold has tohave acceptable biocompatibility controlled degrade rate and mechanical strength in orderto support cell adhesion and cellular differentiation so as new bone can be properlysubstituted at the end The aim of this study is to synthesis Nano powders of and tricalcium phosphate and Strontium fluorapatite and applies them to fabricate compositescaffold with proper strength To this aim both and TCP powders were synthesizedthrough two different routes for each one and characterized Finally the water solventmethod and Si TCP were utilized respectively for further research Studying of TEMimages of and TCP powders reveals that their particle size is less than 100 and 15 nm respectively Furthermore SrFAp powders were synthesized by the mechanical alloyingmethod Then they were characterized according to tests such as Rietveld refinement ofXRD and bioactivity which illustrated that the substituted Sr does not affect the formationof bone like apatite in bioactivity tests In order to fabricate the ceramic scaffolds gelcasting and polymer sponge method were both used at first then the latter method polymer sponge method was selected due to its easier controllability and higher openporosity percent Different compositions of the above powders were applied to fabricatecomposite scaffolds by the use of the polymer sponge method The scaffolds werecharacterized according to compression measuring porosity and soaking in simulated bodyfluid tests The results showed that porous scaffold with the strength of about 6 Mpa couldbe fabricated by the use of TCP powder Moreover considerable increase in the strengthof the scaffold which was more than 30 percent was observed by adding SrFAp to TCPpowders Finally scaffolds with ability to be controlled in different parts as to theircomposition and porosity were fabricated which make it possible to simulate physicalappearance of the bone as well as to have acceptable control over the biological propertiesin different areas Keywords tricalcium phosphate tricalcium phosphate Sr fluorapatite Tissueengineering Nano particle Rietveld Refinement porous ceramic

حسين ادريس، محمدحسين فتحي

وجيه السادات مرتضوي

احمد منشي،مهشيد خرازيها