پديد آورنده :
رحيمي، مصطفي
عنوان :
سنتز و شناسايي كمپلكس‌هاي پالاداسيكل مشتقات بنزيل آميني داراي گروه‌هاي 3و5-دي متيل پيرازول و ديتيزون و مطالعه برهمكنش آن‌ها با BSA و DNA به وسيله نشان‌گرهاي دارويي و فعاليت كاتاليزوري آن‌ها در اكسايش الكل‌ها
مقطع تحصيلي :
كارشناسي ارشد
گرايش تحصيلي :
شيمي معدني
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي
صفحه شمار :
يازده، 92ص.: مصور
استاد مشاور :
شادپور ملك پور
توصيفگر ها :
جايگاه اتصالي
استاد داور :
عبدالرضا حاجي پور، علي حسين كيانفر
تاريخ ورود اطلاعات :
1395/01/29
چكيده انگليسي :
Synthesis and characterization of Palladacyclic complexes of Benzylamine derivatives containing 3 5 dimethylpyrazole and Dithizone Study their interactions with DNA and BSA by medicinal markers and catalytic activities in oxidation of Alcohols Mostafa Rahimi Mostafa rahimi@ch iut ac ir January 2016 Department of Chemistry Isfahan University of Technology Isfahan 2268455 Isfahan IranDegree M Sc Language Farsi Supervisor Dr K Karami karami@cc iut ac ir Advisor Prof Sh Mallakpour Department Graduate Program Coordinator Dr A R Najafi ChermahiniAbstractIn the first section of this thesis di nuclear cyclopalladated chloro bridge complexesderived from primary secondry and tertiary benzylamines were prepared monodentateand bidentate ligands can split the chloro bridges to give monomeric and dimericcomplexes reaction between chloro bridge dimers with dithizone in the 1 1 molar ratioresulted in the Mononuclear Pd II complexes and reaction between chloro bridge dimerswith 3 5 Dimethylpyrazole in the 1 1 molar ratio resulted in the pyrazole bridged Pd II complexes also In second section the phosphorus ylides R3PdCHC O PhR R OMe andPh react with the 1 5 cyclooctadiene complex PdCl2 COD COD C8H12 1 5 cyclooctadiene to give the monomeric cyclooctenyl complexes PdCl2 C8H12 CH PPh3 C O PhR R OMe Ph which synthesized and fullycharacterized by elemental analysis and spectroscopic studies IR and multi nuclearNMR In the second part of the project biological activity of the Pd2 C N C6H4CH CH3 NH2 2 dmPz 2 PdCl2 C8H12 CH PPh3 COC6H4 Ph 4 PdCl2 C8H12 CH PPh3 COC6H4 4 OMe complexes was evaluated by examining theirability to bind to DNA CT DNA using uv visible and thermal denaturation Competitivestudies of sitemarkers of ibuprofen and warfarine and digoxin were also performed toidentify the binding site of the complex to BSA and as a result of the experiments complex 3b have been placed in binding site II and complexe 2d and 2f have beenplaced in binding site III KEYWORDS pyrazole dithizone interaction with DNA interaction with BSA site marker alcohol oxidation
استاد مشاور :
شادپور ملك پور
استاد داور :
عبدالرضا حاجي پور، علي حسين كيانفر
