11675

10722

كارشناسي ارشد

شيمي معدني

اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي

1395

هشت،[47]ص.: مصور،جدول،نمودار

ص.ع.به فارسي و انگليسي

1395/08/10

شيمي

ID10722

46 Novel Dinuclear Cadmium Lawsone Complex Synthesis Crystal Structure Antiproliferative and Biological Evaluations Reza Golbang Department of chemistry Isfahan University of Technology Isfahan 84156 83111 Iran Degree M Sc Language Farsi Supervisor Dr Hossein Chiniforoshan chini@cc iut ac ir AbstractThe synthesis and structural characterizations of Cd II lawsone Law complex in thepresence of ligand of 1 10 phenanthroline phen Cd2 Law 4 phen 2 4CH3OH 1 havebeen studied The complex is in dimeric form that has been structurally characterized byspectral IR TOF Mass and X ray crystallography The interaction of 1 and lawsone ligandwith calf thymus DNA CT DNA and bovine serum albumin BSA was investigated usingUV visible and fluorescence spectrophotometric methods The antimicrobial activities ofcomplex 1 are higher against the different types of Gram positive and Gram negativebacteria than free ligand lawsone and chloramphenicol as reference The cytotoxic effect ofcompound 1 on promyelocytic leukaemia HL 60 colon HCT 8 brain SF 295 andmelanoma MDA MB 435 cancer cell lines was also much higher than cisplatin Keywords Cadmium II complex DNA binding BSA binding Cytotoxicity Lawsone

حسين چيني فروشان

محمد ديناري، فاطمه داور