شماره راهنما :
1232 دكتري
پديد آورنده :
نصيري، فاطمه
عنوان :
ساخت پروتز بريد كربن/كولار و بهينه سازي خواص كششي آن جهت ترميم شكستگي استخوان
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده نساجي
صفحه شمار :
يازده، ۲۱۶ص.: مصور، جدول، نمودار
استاد راهنما :
سعيد آجلي، داريوش سمناني
استاد مشاور :
رحمت الله عمادي، سعيد كرباسي، محسن جهانشاهي
توصيفگر ها :
كامپوزيت بريد لوله اي , فناوري الكتروريسي , كربن/كولار , نانوالياف , خواص مكانيكي , آزمايشات سلولي
استاد داور :
علي اكبر قره آقاجي، مهشيد خرازي ها، مهدي حجازي
تاريخ ورود اطلاعات :
1397/07/14
كد ايرانداك :
ID1232 دكتري
چكيده فارسي :
02 پيوست دو خواص مكانيكي نمونههاي كامپوزيت بريد لولهاي كربن كوالر 791 مراجع 402 چكيده انگليسي 712 يازده
چكيده انگليسي :
226AbstractBone fractures occurred due to accidents job sports accidents illness caducity and so forth Iffracture healing needs surgery using a bone fixation device is neccesary for fracture repairing Currently metal bone plates are the most used repairing device that had many challenges such asstress shielding allergic reactions device fracture in a body need to be repair replace or removedue to clinical reasons Corresponding to large number of bone fracture per annum in the worldand need an optimized device for faster and easier repairing in this thesis an implant designedand produced by using braiding and electrospinning technologies With braiding technology tubular Carbon Kevlar braid fabricated that acted like a bridge and connected two parts of thefractured bone Using such a braid composite have many advantages like reducing textilethickness screw eliminating and tailorable braid composites make it possible to produce aproduction corresponding to end use To access this goal five parameters named adding a matrixto textile braid adding Kevlar to carbon braid structure the carbon Kevlar pattern in braidstructure number of layers and braid angle investigated Polymethylmethacrilate reinforced with2 Graphene Oxide used to composite braid samples After obtaining each parameters effect with Vikor fuzzy software samples were optimized The best sample in braid part was a tubularcomposite with a 2 2 pattern of carbon and kevlar 4 layers and 56 75 braid angle which thenplaced on a cow fractured bone and biomechanical tests were done on it Tensile stress modulusand strain were 490 64 MPa 2 74 and 29 07 GPa respectively Flexural Stress strain andmodulus were 308 21 MPa 1 76 and 17 74 GPa respectively 46 57 was the energyabsorption of a fractured bone with the best braid sample Results showed that this compositetubular braid with properties in the range of natural bone the main goal of this research could bea proper replacement for metal bone plates The other goal of this research was producing a tissueengineered scaffold for acceleration the healing process by providing a better cell attachment growth and proliferation during the repairing time For this PCL HA bioactive nanoparticles andGO nanoplates were used and samples were studied with SEM AFM Raman Spectroscopy electrical conductivity thermal evaluation and cellular tests First biomaterials concentrations inelectrospinning solution optimized then by investigating surface morphology nanofiber diameter distribution percentages surface and volume porosity samples were selected corresponded to bonetissue properties In continues electrospinning parameters including electrospinning distance thevoltage and flow rate were optimized Also for understanding nanofillers effects PCL PCL HAand PCL HA GO scaffolds were tested and compared The results showed that adding nanofillersimproved scaffold surface morphology increased surface roughness decreased fiber thickness increased porosities refined hydrophilicity and electrical conductivity and as a result improvedscaffold function in reactions with cells The results showed that scaffolds not only had no toxiceffect on cells but they improved cell adhesion growth and proliferation The best function belongsto sample with 0 4 wt GO 1 0 wt HA and 7 6 wt PCL which showed a uniform distributionof cells on its surface 14 days after cell seeding This selective sample has average diameter of178 nm with 90 distribution 96 and 94 as a surface and volume porosity 19 water contactangle 3 6 MPa tensile stress 6 7 mS cm electrical conductivity 184 80 cell viability 279 ALP activity and 7 2 105 alive cell 14 days after human mesenchymal stem cell seeding Keywords Tubular composite braid Electrospining Technology Carbon Kevlar Nanofibers Mechanical test Cellular assay
استاد راهنما :
سعيد آجلي، داريوش سمناني
استاد مشاور :
رحمت الله عمادي، سعيد كرباسي، محسن جهانشاهي
استاد داور :
علي اكبر قره آقاجي، مهشيد خرازي ها، مهدي حجازي
