13983

12703

كارشناسي ارشد

فيزيك هسته اي

اصفهان: دانشگاه صنعتي اصفهان، دانشكده فيزيك

1397

چهارده، ۸۰ص.: مصور، جدول، نمودار

ظفرالله كلانتري

مريم حسنوند

داور(اختياري): محمدحسن علامت ساز، آذر تفريحي

1397/07/24

كتابنامه

فيزيك

فيزيك

ID12703

Calculation of the Optimum Energy and Therapeutic Gain in Proton Therapy of Brain Tumor Using Snyder Phantom in MCNPX Code Samaneh Rezaei samaneh rezaei@ph iut ac ir Date of Submission June 25 2018 Department of Physics Isfahan University of Technology Isfahan IranDegree M Sc Language PersianSupervisor Seyed Zafarollah Kalantari zafar@cc iut ac irAbstractIn Brain cancer treatment by Proton Therapy the proper energy is calculated according to thevolume depth and place of tumor One of the desired calculating methods is Monte CarloSimulations and one of the popular codes which works with this method is MCNPX which is usedin this thesis At first the head of a mature patient has been simulated using Cylinder phantom made of water Atumor with the radius of 2 54 cm has been simulated in the depth of 8 8 cm of brain and thepatient s head is exposed to proton beams with energies from 110 MeV to 135 MeV with the stepsof 1 MeV Then graphs of proton and secondary neutrons doses produced in brain have beenplotted At the next stage the simulation is done for the same conditions by Snyder phantom Then theresults of proton therapy for two phantoms with different geometries and materials are compared The comparison has shown that we gain two times greater TG when using Snyder phantom SinceSnyder phantom is much closer to the real geometry and components of the brain this differenceshows that using Cylinder phantom is not a good approximation in calculations in similar cases Finally the optimum energy of proton beam for the most destruction of tumor and the least negativeeffect on the healthy tissue is determined between 130 MeV to 132 MeV It is important to say that in this thesis dose of the produced secondary neutrons which are thesources of the secondary cancer is also calculated The results of these calculations have shown thatthe secondary neutron dose in proton therapy is very small and it is about 0 01 of proton dose andthis is one of the strength points of this treatment method Finally by analyzing the results of proton therapy and BNCT Boron Neutron Capture Therapy it isshown that in proton therapy TG is greater and secondary neutrons dose is much less incomparison with BNCT Keywords proton therapy MCNPX Snyder Phantom secondary neutrons

ظفرالله كلانتري

مريم حسنوند

داور(اختياري): محمدحسن علامت ساز، آذر تفريحي