14469

1364 دكتري

دكتري

تكنولوژي نساجي

اصفهان : دانشگاه صنعتي اصفهان

1397

نوزده، 112ص.: مصور، جدول، نمودار

محمد ذره‌بيني، داريوش سمناني

عباسعلي پورآذر، ناهيد اكبري، محسن نصر اصفهاني

ناهيد اسكندري، احمد محب، عبدالكريم حسيني

1398/01/18

كتابنامه

نساجي

مهندسي نساجي

1398/01/19

ID1364 دكتري

111AbstractSuccess of a blood transfusion depends on significant reduction of white blood cells Differences in density structure geometry and size of white and red blood cells are the reasonsbehind different behavior of these cells during separation process High flexibility of red bloodcells facilitates their passage through very narrow channels Characteristics of the white bloodcells allow their separation from blood using fibrous filter media Thus optimization of whiteblood cell filtration is of vital importance as far as separation performance is concerned Conducted researches in the field of white blood cell separation modeling are rather scarce Optimization of white blood cell filtration depends up on modelling of fibrous media structuralparameters and their effect on separation process In this work nano spun polyacrylonitrile dimethylformamide fibrous filter media wereproduced The effects of structural parameters such as fiber fineness fiber orientation poresize and surface roughness on white cell separation efficiency of the produced filters wereevaluated using image processing method White cell separation performance and safe use ofthe nanofibrous filters were assured using a set of designed experiments together with theequations governing filtration principals and the relevant internationally accepted standards Response surface methodology was used to develop a statistical model capable of predictingthe most influential factors affecting white blood cell filtration It was concluded that whiteblood cell separation efficiency is highly affected by the pore size number of constituent layersand their weight per unit area Nanofibrous filters were found to be capable of reducing thenumber of white blood cell by five logarithm which is two logarithm less than the statedthreshold in the CE standard It was also established that while the nanofibrous filters like theircommercial leukofilter counterparts possess higher separation ability than the stated thresholdsin the standards the nanofibrous filters were lighter than the commercial leukofilter by 94 weight wise It was deduced that the asymmetric filter media compose of nanofibrous filters incomparison to symmetrical filter media and the commercial leukofilter membrane havesuperior separation ability Model generated results pointed to conformity of separationmechanism of the nanofibrous filters with principals governing depth filtration and standardblocking Results of the response surface methodology pointed to conformity of number ofresidual white blood cell red blood cell recovery percent and filtrate volume with Quadratic reduced 2FI and reduced linear functions respectively It was also established that fiber finenessand layers weight per unit area of the nanofibrous filters significantly affect white blood cellfiltration Key words Blood filtration Leukocyte reduction Electrospinning Structural parameters Image processing Separation Modelling Response surface methodology White blood cellresidual

محمد ذره‌بيني، داريوش سمناني

عباسعلي پورآذر، ناهيد اكبري، محسن نصر اصفهاني

ناهيد اسكندري، احمد محب، عبدالكريم حسيني