15112

13592

كارشناسي ارشد

شناسايي و انتخاب مواد

اصفهان : دانشگاه صنعتي اصفهان

1398

چهارده، 97ص.: مصور، جدول، نمودار

شيدا لباف، فتح الله كريم زاده

مهشيد خرازيها، عباس بهرامي

1398/07/07

كتابنامه

مهندسي مواد

مهندسي مواد

1398/07/08

2563776

AbstractCancer therapy is one of the major problems in human societies Bone is a susceptible site formetastasis of cancer cells One of the main uses of magnetic ferrofluids is in magnetic hyperthermiafor cancerous tumor treatment whereby heat generation occurs following exposure to an alternatingmagnetic field following injection into the area of interest This will lead to an increase in temperaturein the range of 41 46 C and cause cancerous cell death Magnetic nanoparticles iron oxide as thestructural core with a shell layer will enable the production of a stable structure In order to improvethe destruction of tumor tissue in bone and simultaneously enable tissue repair a bioactive glasscoating was selected Due to biodegradability biocompatibility high surface area and the ability toencapsulate drug and other biological factors n addition to hydroxyapatite formation followingimmersion in body fluid bioactive glass mesoporous structures appear to be an ideal candidate Theaim of the current study was to fabricate and characterize magnetic nanoparticles with mesoporousbioactive glass coating and to investigate drug loading and release from the resultant structure Here doxorubicin was chosen as a model drug a very good option for bone tumor treatment as it is alsobeing utilized in high dose for chemotherapy treatment so it will enable a more efficient therapy Inthis regard initially iron oxide nanoparticles were synthesized using co precipitation method and thenembedded in BGs through sol gel synthesis process X ray diffraction scanning electron microscopy transmission electron microscopy and X ray emission spectroscopy were utilized to fully characterizethe structures Particle with A spherical morphology with an average particle size of less than 13 nmwith a coating of 25 43 nm was produced In order to ensure that bioactive glass coating was created thermal gravimetric and Fourier transform were performed The magnetic properties and specific losspower for the optimized structure was found to be 67 emu g and 5 17 emu g respectively The zetapotential of the particles was found to be 22 4 mV Further to prove the hydroxyapatite layerformation following immersion in simulated body fluid X ray diffraction pattern and plasma massspectrometry techniques were utilized Cytotoxicity tests confirmed the non cytotoxic nature of theparticles Finally doxorubicin loading and release was performed on aminated and non aminatedstructures The release profile was obtained following testing in two different pH conditions of 5 1and 8 4 release key words Magnetite Magnetic Nanoparticles Functional Method Bioactive Glass Doxorubicin

شيدا لباف، فتح الله كريم زاده

مهشيد خرازيها، عباس بهرامي