15216

1471 دكتري

دكتري

الكترونيك

اصفهان : دانشگاه صنعتي اصفهان

1398

چهارده، 153 ص.: مصور، جدول، نمودار

رسول دهقاني، ابراهيم غفارزاده

مسعود سيدي

عبدالرضا نبوي، اصغر غلامي، وحيد غفاري نيا

1398/07/29

كتابنامه

مهندسي برق

مهندسي برق و كامپيوتر

1398/07/29

2570577

Design and simulation of CMOS Multi sensors for Cellular Analysis Saghi Forouhi s forouhi@ec iut ac ir Date of Submission 9 17 2019 Department of Electrical and Computer Engineering Isfahan University of Technology 84156 83111 Isfahan Iran1st Supervisor Dr Rasoul Dehghani dehghani@cc iut ac ir2nd Supervisor Dr Ebrahim Ghafar Zadeh egz@cse yorku caAdvisor Dr Sayed Masood Sayedi m sayedi@cc iut ac irDepartment Graduate Program coordinator Dr Gholamreza Yousefi Department of Electrical and Computer Engineering Isfahan University of Technology 84156 83111 Isfahan Iran Biologically Inspired Sensors and Actuators BioSA Department of Electrical Engineering and ComputerScience EECS Lassonde School of Engineering York University Toronto ON M3J 1P3 CanadaAbstractBy offering the advantages of low complexity and high precision CMOS capacitive sensor arrays can beconsidered as the best candidate for high throughput screening of cellular activities Since the cultured cells aresensitive to temperature monolithic implementation of capacitive and temperature sensors on a single chip canincrease the accuracy of the system This thesis aims to design a multi sensor consisting of a capacitivebiosensor and a temperature sensor in CMOS technology to conduct cellular analysis as a part of a lab on chip LoC platform In this regard two capacitive sensors and one temperature sensor are proposed in this thesis The proposed capacitive biosensor interfaces are designed based on charge based capacitance measurement CBCM method The first capacitive sensor improves the functionality of a fully differential core CBCMsensor and its resolution But it suffers from a limited input dynamic range IDR like the other conventionalcore CBCM circuits So a novel current mode core CBCM sensor is proposed to overcome this limitationwithout losing the resolution As the third innovation of this project a new MOSFET based temperature to frequency converter TFC is proposed here which has a highly linear response R2 1 in typical conditions Key Words Lab on chip cellular analysis capacitive biosensor charge based capacitance measurement MOSFET based temperature sensor Introduction CMOS capacitive sensors have been receiving much attention due to their high resolution low complexity and low temperature dependency Different methods have been reported todetect very small capacitances and convert them to a readable signal for LoC applications Among these methods CBCM has drawn considerable attention for high throughputscreening in array structures by offering high accuracy and low complexity In cellular monitoring the biological cells behave as insulating structures between theplates of capacitive sensors Any changes in the morphology and behavior of the cells suchas cell growth or death can change the permittivity of the measured capacitance Environmental temperature is one of the effective parameters in cellular activities So weneed thermal management in LoCs The basic core of this method is depicted in Figure 1 The core of this kind of capacitivesensor is connected to a sensing CS and a reference capacitor CR Two pairs of PMOS M3and M4 and NMOS M1 and M2 switches form the core of the CBCM method to charge ordischarge these capacitors respectively These switches are controlled by two clock pulses 1 and 2 The averaged currents of the two branches of this circuit is and iR over one

رسول دهقاني، ابراهيم غفارزاده

مسعود سيدي

عبدالرضا نبوي، اصغر غلامي، وحيد غفاري نيا