پديد آورنده :
موسوي، فاطمه
عنوان :
استخراج پلي‌ساكاريدها از ريشه‌ي گياه سريش ايراني (Eremurus persicus Bioss ) و تهيه‌ي داربست سلولي به كمك پليمرسنتزي پلي‌وينيل‌الكل
مقطع تحصيلي :
كارشناسي ارشد
گرايش تحصيلي :
گياهان دارويي و صنعتي
محل تحصيل :
اصفهان : دانشگاه صنعتي اصفهان
صفحه شمار :
پانزده، 95ص. : مصور، جدول، نمودار
استاد راهنما :
حسين بشري، عليرضا علافچيان
استاد مشاور :
اميرحسين جلالي
توصيفگر ها :
الكتروريسي , پليمر سنتزي پلي‌وينيل‌الكل , داربست سلولي , گياه سريش ايراني , موسيلاژ
استاد داور :
محمدرضا وهابي، مهدي بازرگاني پور
تاريخ ورود اطلاعات :
1400/03/12
رشته تحصيلي :
مهندسي منابع طبيعي
دانشكده :
مهندسي منابع طبيعي
تاريخ ويرايش اطلاعات :
1400/03/17
چكيده انگليسي :
Extraction of polysaccharides from the roots of Iranian sageplant Eremurus persicus Bioss and preparation of cell scaffold using polymer synthesis of polyvinyl alcohol Seyedeh Fatemeh Mousavi mosavi fatemeh1995@gmail com March 2021 Department of Natural Resources Isfahan University of Technology Isfahan 84156 83111 IranDegree MSc Language PersianDr Hossein Bashari hbashari@iut ac irDr Alireza Allafchian allafchian@iut ac irAbstractExtensive research in the field of tissue engineering has been conducted in recent years and organ destruction and repair is one of the main challenges of medical science today Replacing damaged tissue with new tissue it has many limitations in terms of cost andpublic access Using three main factors cell scaffold and growth factors tissueengineering science tries to facilitate the healing process of injuries and losses organs Tissue engineering seeks to make living replacement parts to the body The first point thatmust be considered in making the cell substrate for cell repair and growth is that istingredients must be completely biocompatible and not toxic to the cell which is called cellscaffold One of the most common methods in tissue engineering is the production ofscaffolding by electrospinning method Today a combination of biological and traditionalpolymers are used to produce scaffolding Synthetic polymers increase the strength ofscaffolds and biopolymers increase cell adhesion and reduce the body s immune responses In this study it is intended with the help of synthetic polymer polyvinyl alcohol PVA and mossilage in the root of the Iranian safflower plant with the scientific name Eremuruspersicus collected from the Khoroose Galue paws located in Semirom city of Isfahanprovince to produce scaffold and study its physical and chemical properties E persicusplants is one of the most important and exclusive rangeland plants in thecentral regions ofIran which is used in the medical industry due to its high carbohydrate content In thisstudy after collecting the roots of the studied plant from the Khoroose Galue paws area mucilage was extracted by using ethanol 96 Then by means of PVA polymerizationand root mucilage of Iranian sage plant different volume ratios of mucilage solution PVA 50 50 60 40 40 40 and pure PVA 12 w v and 3 mucilage solution w v nanofibers were produced FESEM results showed that 50 50 mucilage PVAnanofibers had an average diameter of 184 5nm electrical conductivity 335 5 s viscosity 1057 5 mm min 1 surface tension 47 967 03 mN m 1 contact angle 50 305 4 7and tensile strength 138 73 cN XRD results showed that PVA nanofibers and PVAmucilage had no crystal structure The FTIR results indicate that There was no chemicalreaction between the resulting nanofibers The results of cell viability also showed that thecombination of these two polymers in a ratio of 50 50 does not cause toxicity for thecell and can be considered a good option for the growth of epithelial cells Keywords Electrospinning Polyvinyl Alcohol Stencil Polymer Cell Scaffolding Iranian Shaving Plant Mucilage
استاد راهنما :
حسين بشري، عليرضا علافچيان
استاد مشاور :
اميرحسين جلالي
استاد داور :
محمدرضا وهابي، مهدي بازرگاني پور
