Milk fever is one of the essential metabolic diseases in dairy herds globally, which imposes a lot of financial losses on this industry every year, which according to herd management, can affect the preva‎lence of the disease. In order to study the effect of metabolic abnormalities of milk fever on production and reproductive traits and to estimate the financial loss due to milk fever, biological and economic information related to 4 industrial farms of Holstein breed located in Isfahan province during the years 1396 to 1398 were used. For this purpose, a suitable model was described that describes the production conditions at the level of dairy farms. The average incidence of milk fever in 4 herds was estimated to be 1.31%. The effect of some influential factors on the incidence of milk fever such as herd effect, calving season, calving year, stillbirth, and dry period length was investigated. The results of logistic regression showed that all factors in the model had a significant effect on the occurrence of milk fever. The odds ratio showed that the incidence of milk fever increased compared to healthy animals despite the studied factors. The results of mean least-squares showed that the occurrence of evaporation had adverse and significant effects on milk production and reproductive traits. The effect of this disease on traits related to milk production decreased by 513.5 ± 178.8 kg per head of livestock (p <0.001) and in parallel caused a significant reduction (p <0.001) by 6.8%. 27.5 kg in milk fat and 20.5 6 6.4 kg in milk protein (p <0.004). In this study, the occurrence of milk fever was a significant increase (p <0.0001) in the number of inseminations leading to pregnancy by 0.22 ± 0.08 inoculations and, in parallel, an increase of 11.8 2 2.7 days in The number of open days, caused

علي صادقي سفيدمزگي

غلامرضا قرباني خراجي،مجتبي كافي

سعيد انصاري مهياري، عليرضا عليپور