Hyperthermia is a new method in cancer treatment that increases the temperature of cancerous tissue without damaging healthy tissues and without the need for surgery, resulting in a faster recovery compared to older treatments. Magnetic nanoparticles can be used to achieve the necessary temperature to destroy cancerous tissues. The aim of this study was to fabricate and characterize poly-nipam-poly-caprolactone magnetic nanocarriers. First, magnetite magnetic nanoparticles were synthesized using a conventional co-precipitation method and eva‎luated for purity, size, morphology, and magnetic properties using X-ray diffraction, scanning electron microscopy, and vibrating sample magnetometry. The results showed that the nanoparticles had an average size of 10±72 nm and a saturation magnetization of 69.63 emu/g. The X-ray diffraction confirmed the spinel structure of magnetite. Then, 5, 10, and 15 wt% magnetite nanoparticles were incorporated into poly-nipam-poly-caprolactone using electrospinning. The presence of the coating was confirmed again by X-ray diffraction, scanning electron microscopy, and vibrating sample magnetometry. The results showed that the size of the nanoparticles decreased from 390 nm to 310 nm with increasing nanoparticle concentration due to changes in solution viscosity. The presence of magnetite nanoparticles in the polymer coating was confirmed by X-ray diffraction and infrared spectroscopy, and the saturation magnetization of nanoparticles containing 15 wt% magnetite was 2.41 emu/g, which is suitable for hyperthermia applications. Finally, doxorubicin, an anti-cancer drug, was loaded into temperature-sensitive poly-nipam-poly-caprolactone magnetic nanoparticles to increase therapeutic efficiency. Citric acid was used to create a surface coating that allowed drug loading, and Fourier transform infrared spectroscopy was used to confirm chemical bonding between the drug and nanoparticles. The release of the drug was controlled at two different pH values (5.1 and 7.1) and two different temperatures (37°C and 41°C) over a period of 96 hours. The results showed that the controlled release of the drug was due to the swelling of the structure, and in the absence of magnetite nanoparticles, the drug release was 18.3% and 13.8% at pH 5.1 and 7.1, respectively, while in the presence of magnetite nanoparticles, the drug release was 15% and 9.98%, respectively. Moreover, in the absence of magnetite nanoparticles, the drug release was 24% and 18.22%, respectively, while in the presence of magnetite nanoparticles, the drug release was 19% and 15.53% at pH 5.1 and 7.1, respectively, over a period of 5 hours at a temperature of 41°C.

شيدا لباف , محمدحسين عنايتي

كيوان رئيسي , عليرضا علافچيان